Department of Environmental Health Sciences, Columbia Center for Children's Environmental Health. Department of Environmental Health Sciences, Mailman School of Public Health, 722 West 168th St., New York, NY 10032 USA.
Environ Health Perspect. 2012 Feb;120(2):290-5. doi: 10.1289/ehp.1103705. Epub 2011 Sep 6.
Research suggests that prenatal phthalate exposures affect child executive function and behavior.
We evaluated associations between phthalate metabolite concentrations in maternal prenatal urine and mental, motor, and behavioral development in children at 3 years of age.
Mono-n-butyl phthalate (MnBP), monobenzyl phthalate (MBzP), monoisobutyl phthalate (MiBP), and four di-2-ethylhexyl phthalate metabolites were measured in a spot urine sample collected from 319 women during the third trimester. When children were 3 years of age, the Mental Development Index (MDI) and Psychomotor Development Index (PDI) were measured using the Bayley Scales of Infant Development II, and behavior problems were assessed by maternal report on the Child Behavior Checklist.
Child PDI scores decreased with increasing loge MnBP [estimated adjusted β-coefficient = -2.81; 95% confidence interval (CI): -4.63, -1.0] and loge MiBP (β = -2.28; 95% CI: -3.90, -0.67); odds of motor delay increased significantly [per loge MnBP: estimated adjusted odds ratio (OR) = 1.64; 95% CI: 1.10, 2.44; per loge MiBP: adjusted OR =1.82; 95% CI: 1.24, 2.66]. In girls, MDI scores decreased with increasing loge MnBP (β = -2.67; 95% CI: -4.70, -0.65); the child sex difference in odds of mental delay was significant (p = 0.037). The ORs for clinically withdrawn behavior were 2.23 (95% CI: 1.27, 3.92) and 1.57 (95% CI: 1.07, 2.31) per loge unit increase in MnBP and MBzP, respectively; for clinically internalizing behaviors, the OR was 1.43 (95% CI: 1.01, 1.90) per loge unit increase in MBzP. Significant child sex differences were seen in associations between MnBP and MBzP and behaviors in internalizing domains (p < 0.05).
Certain prenatal phthalate exposures may decrease child mental and motor development and increase internalizing behaviors.
研究表明，产前邻苯二甲酸酯暴露会影响儿童的执行功能和行为。
我们评估了孕妇尿液中邻苯二甲酸酯代谢物浓度与儿童 3 岁时的精神、运动和行为发育之间的关系。
在 319 名孕妇的妊娠晚期采集一份尿样，检测单丁基邻苯二甲酸酯（MnBP）、单苄基邻苯二甲酸酯（MBzP）、单异丁基邻苯二甲酸酯（MiBP）和四种二乙基己基邻苯二甲酸酯代谢物的浓度。当孩子 3 岁时，使用贝利婴幼儿发展量表第二版测量精神发育指数（MDI）和运动发育指数（PDI），并通过母亲报告的儿童行为检查表评估行为问题。
儿童 PDI 评分随 MnBP [估计调整β系数=-2.81；95%置信区间（CI）：-4.63，-1.0]和 MiBP 的对数增加而降低（β=-2.28；95%CI：-3.90，-0.67）；运动发育迟缓的几率显著增加[每 loge MnBP：估计调整后的比值比（OR）=1.64；95%CI：1.10，2.44；每 loge MiBP：调整后的 OR=1.82；95%CI：1.24，2.66]。在女孩中，MDI 评分随 MnBP 的对数增加而降低（β=-2.67；95%CI：-4.70，-0.65）；在精神发育迟缓的几率方面存在显著的儿童性别差异（p=0.037）。MnBP 和 MBzP 每增加一个对数单位，临床上退缩行为的 OR 分别为 2.23（95%CI：1.27，3.92）和 1.57（95%CI：1.07，2.31）；对于临床上的内化行为，MBzP 每增加一个对数单位，OR 为 1.43（95%CI：1.01，1.90）。在 MnBP 和 MBzP 与内化行为领域的行为之间的关联中，观察到显著的儿童性别差异（p<0.05）。
某些产前邻苯二甲酸酯暴露可能会降低儿童的精神和运动发育，并增加内化行为。
