癫痫发病率：系统评价和荟萃分析。
Incidence of epilepsy: a systematic review and meta-analysis.
机构信息
Centre for Geographic Medicine Research-Coast, KEMRI, Kilifi 80108, Kenya.
出版信息
Neurology. 2011 Sep 6;77(10):1005-12. doi: 10.1212/WNL.0b013e31822cfc90.
Abstract
OBJECTIVE
To estimate the pooled incidence of epilepsy from published studies and investigate sources of heterogeneity in the estimates.
METHODS
We searched online databases for incidence studies and used meta-analytic methods to analyze the data.
RESULTS
Thirty-three articles met the entry criteria. The median incidence of epilepsy was 50.4/100,000/year (interquartile range [IQR] 33.6-75.6), while it was 45.0 (IQR 30.3-66.7) for high-income countries and 81.7 (IQR 28.0-239.5) for low- and middle-income countries. Population-based studies had higher incidence estimates than hospital-based studies (p = 0.02) while retrospective study design was associated with lower estimates than prospective studies (p = 0.04).
CONCLUSION
We provide data that could potentially be used to assess the burden and analyze the trends in incidence of epilepsy. Our results support the need for large population-based incidence studies of epilepsy.
摘要
目的
从已发表的研究中估计癫痫的发病情况，并探讨估计值差异的来源。
方法
我们在线数据库中搜索了发病率研究，并使用荟萃分析方法对数据进行了分析。
结果
符合纳入标准的文章有 33 篇。癫痫的中位发病率为 50.4/100,000/年（四分位距 [IQR] 33.6-75.6），高收入国家为 45.0（IQR 30.3-66.7），低收入和中等收入国家为 81.7（IQR 28.0-239.5）。基于人群的研究的发病估计值高于基于医院的研究（p = 0.02），而回顾性研究设计与前瞻性研究相比，估计值较低（p = 0.04）。
结论
我们提供的数据可能被用于评估癫痫的负担和分析其发病趋势。我们的结果支持需要开展大规模的基于人群的癫痫发病率研究。
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