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益生菌在泌尿生殖系统保健中的作用。

Role of probiotics in urogenital healthcare.

作者信息

Waigankar Santosh S, Patel Vimal

机构信息

Department of Urology, Jaslok Hospital and Research Center, Mumbai, India.

出版信息

J Midlife Health. 2011 Jan;2(1):5-10. doi: 10.4103/0976-7800.83253.

DOI:10.4103/0976-7800.83253
PMID:21897732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3156505/
Abstract

Urogenital infections are one of the most common causes for a woman to visit a gynecologist or a urologist. The well-known association between abnormal vaginal microbial flora and its formidable risk in the increased incidence of urinary tract infection underscores the importance of understanding the microbial flora and the efforts needed to maintain it, for ensuring urogenital health. Surprisingly in spite of the increased incidence urogenital infections receive very less attention from the medical fraternity. Growing awareness among people and newer advances in the medical field has brought them into the limelight. The importance of replenishing these depleting commensals with 'probiotics' has resurfaced in a big way. As the days go by science and medicines will touch new milestones, which will include probiotics. The value of a probiotics cannot be taken at face value. Probiotics must not be considered a panacea for treating urogenital infections. However, the available data promises that it will be a strong option in improving and maintaining urogenital health.

摘要

泌尿生殖系统感染是女性去看妇科医生或泌尿科医生的最常见原因之一。异常阴道微生物群与其在尿路感染发病率增加方面的巨大风险之间的众所周知的关联,凸显了了解微生物群以及为确保泌尿生殖系统健康而维持它所需努力的重要性。令人惊讶的是,尽管泌尿生殖系统感染的发病率有所上升,但医学界对其关注却非常少。人们意识的提高和医学领域的新进展使它们成为了焦点。用“益生菌”补充这些正在减少的共生菌的重要性已再次凸显。随着时间的推移,科学和医学将达到新的里程碑,其中将包括益生菌。益生菌的价值不能只看表面。益生菌不能被视为治疗泌尿生殖系统感染的万灵药。然而,现有数据表明它将是改善和维持泌尿生殖系统健康的有力选择。

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本文引用的文献

1
Vaginal microbiota and the use of probiotics.阴道微生物群与益生菌的应用
Interdiscip Perspect Infect Dis. 2008;2008:256490. doi: 10.1155/2008/256490. Epub 2009 Mar 29.
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Novel insight into the vaginal microflora in postmenopausal women under hormone replacement therapy as analyzed by PCR-denaturing gradient gel electrophoresis.通过聚合酶链反应-变性梯度凝胶电泳分析激素替代疗法下绝经后妇女阴道微生物群的新见解。
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Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.Toll样受体9信号传导介导益生菌在小鼠实验性结肠炎中的抗炎作用。
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Lactobacillus plantarum 299: beneficial in vitro immunomodulation in cells extracted from inflamed human colon.植物乳杆菌299:对从发炎的人类结肠中提取的细胞具有有益的体外免疫调节作用。
J Gastroenterol Hepatol. 2004 Feb;19(2):166-73. doi: 10.1111/j.1440-1746.2004.03181.x.
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Phase 2 clinical trial of a vaginal mucosal vaccine for urinary tract infections.用于治疗尿路感染的阴道黏膜疫苗的2期临床试验。
J Urol. 2003 Sep;170(3):867-9. doi: 10.1097/01.ju.0000075094.54767.6e.
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Association between acquisition of herpes simplex virus type 2 in women and bacterial vaginosis.女性感染单纯疱疹病毒2型与细菌性阴道病之间的关联。
Clin Infect Dis. 2003 Aug 1;37(3):319-25. doi: 10.1086/375819. Epub 2003 Jul 15.
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Drug resistance amongst uropathogens isolated from women in a suburban population: laboratory findings over 7 years.从郊区女性人群中分离出的尿路病原体的耐药性:7年的实验室研究结果
Can J Urol. 1997 Dec;4(4):432-437.
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Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women.口服鼠李糖乳杆菌GR-1和发酵乳杆菌RC-14可显著改变阴道菌群:对64名健康女性进行的随机、安慰剂对照试验。
FEMS Immunol Med Microbiol. 2003 Mar 20;35(2):131-4. doi: 10.1016/S0928-8244(02)00465-0.
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Bacterial vaginosis is a strong predictor of Neisseria gonorrhoeae and Chlamydia trachomatis infection.细菌性阴道病是淋病奈瑟菌和沙眼衣原体感染的有力预测指标。
Clin Infect Dis. 2003 Mar 1;36(5):663-8. doi: 10.1086/367658. Epub 2003 Feb 7.
10
Improved understanding of the bacterial vaginal microbiota of women before and after probiotic instillation.对女性在益生菌植入前后阴道微生物群的了解得到改善。
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