钯催化的 2-卤代苯乙炔与 2-炔基苯甲酰胺反应：一种高效构建茚并[1,2-c]氮杂卓-3(2H)-酮的方法。
Palladium-catalyzed reaction of 2-alkynylhalobenzene with 2-alkynylbenzamide: an efficient approach to indeno[1,2-c]azepin-3(2H)-ones.
机构信息
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.
出版信息
Chem Commun (Camb). 2011 Oct 21;47(39):11137-9. doi: 10.1039/c1cc14480d. Epub 2011 Sep 6.
PMID:21897941
Abstract
A novel and efficient route for rapid access to indeno[1,2-c]azepin-3(2H)-ones is described, which proceeds through a palladium-catalyzed tandem reaction of 2-alkynylhalobenzene with 2-alkynylbenzamide in the presence of PPh(3) or PCy(3). The indeno[1,2-c]azepin-3(2H)-ones which incorporate both indene and unsaturated seven-membered ring lactam skeletons are obtained in good to excellent yields.
摘要
描述了一种新颖、高效的合成茚并[1,2-c]氮杂卓-3(2H)-酮的方法，该方法通过在 PPh(3) 或 PCy(3) 的存在下，钯催化 2-卤代炔基苯与 2-炔基苯甲酰胺的串联反应进行。所得到的茚并[1,2-c]氮杂卓-3(2H)-酮包含茚和不饱和的七元环内酰胺骨架，收率良好至优秀。
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