• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Genetic variant in PNPLA3 is associated with nonalcoholic fatty liver disease in China.

作者信息

Li Yiling, Xing Chao, Cohen Jonathan C, Hobbs Helen H

出版信息

Hepatology. 2012 Jan;55(1):327-8. doi: 10.1002/hep.24659.

DOI:10.1002/hep.24659
PMID:21898508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3245325/
Abstract
摘要

相似文献

1
Genetic variant in PNPLA3 is associated with nonalcoholic fatty liver disease in China.PNPLA3基因变异与中国的非酒精性脂肪性肝病相关。
Hepatology. 2012 Jan;55(1):327-8. doi: 10.1002/hep.24659.
2
Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent.鉴定非洲裔和西班牙裔个体中与欧洲血统非酒精性脂肪性肝病相关的变异。
Hepatology. 2013 Sep;58(3):966-75. doi: 10.1002/hep.26440. Epub 2013 Jul 16.
3
Four-Week Omega-3 Supplementation in Carriers of the Prosteatotic PNPLA3 p.I148M Genetic Variant: An Open-Label Study.携带致脂肪变性 PNPLA3 p.I148M 基因突变的个体中进行为期四周的欧米伽-3 补充：一项开放标签研究。
Lifestyle Genom. 2019;12(1-6):10-17. doi: 10.1159/000502008. Epub 2019 Aug 27.
4
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.PNPLA3基因变异会使人易患非酒精性脂肪性肝病。
Nat Genet. 2008 Dec;40(12):1461-5. doi: 10.1038/ng.257. Epub 2008 Sep 25.
5
Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study.载脂蛋白基因 PNPLA3 多态性与少数民族非酒精性脂肪性肝病的关系：胰岛素抵抗动脉粥样硬化家族研究。
Liver Int. 2011 Mar;31(3):412-6. doi: 10.1111/j.1478-3231.2010.02444.x. Epub 2011 Jan 13.
6
Genetic variants in PNPLA3 and risk of non-alcoholic fatty liver disease in a Han Chinese population.载脂蛋白 PNPLA3 基因变异与汉族人群非酒精性脂肪性肝病的风险。
PLoS One. 2012;7(11):e50256. doi: 10.1371/journal.pone.0050256. Epub 2012 Nov 30.
7
PNPLA3, the triacylglycerol synthesis/hydrolysis/storage dilemma, and nonalcoholic fatty liver disease.载脂蛋白 L3（PNPLA3）、甘油三酯合成/水解/储存的困境与非酒精性脂肪性肝病。
World J Gastroenterol. 2012 Nov 14;18(42):6018-26. doi: 10.3748/wjg.v18.i42.6018.
8
Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals.GCKR 和 PNPLA3 基因变异与肥胖个体非酒精性脂肪性肝病易感性相关。
Am J Clin Nutr. 2014 Apr;99(4):869-74. doi: 10.3945/ajcn.113.079749. Epub 2014 Jan 29.
9
Interactions of allelic variance of PNPLA3 with nongenetic factors in predicting nonalcoholic steatohepatitis and nonhepatic complications of severe obesity.载脂蛋白 PNPLA3 等位基因变异与非遗传因素相互作用对预测非酒精性脂肪性肝炎和严重肥胖非肝脏并发症的价值。
Obesity (Silver Spring). 2013 Sep;21(9):1935-41. doi: 10.1002/oby.20327. Epub 2013 May 29.
10
No correlation between PNPLA3 rs738409 genotype and fatty liver and hepatic cirrhosis in Japanese patients with HCV.在日本丙型肝炎患者中，PNPLA3 rs738409 基因型与脂肪肝和肝硬化之间无相关性。
PLoS One. 2013 Dec 11;8(12):e81312. doi: 10.1371/journal.pone.0081312. eCollection 2013.

引用本文的文献

1
Identification of NUV-244 as a PNPLA3 I148M degrading small molecule.鉴定NUV-244为一种可降解PNPLA3 I148M的小分子。
iScience. 2025 Apr 8;28(5):112384. doi: 10.1016/j.isci.2025.112384. eCollection 2025 May 16.
2
Predictive value of triglyceride glucose index in non-obese non-alcoholic fatty liver disease.甘油三酯葡萄糖指数在非肥胖非酒精性脂肪性肝病中的预测价值
BMJ Open. 2025 Apr 8;15(4):e083686. doi: 10.1136/bmjopen-2023-083686.
3
The ubiquitin E3 ligase BFAR promotes degradation of PNPLA3.泛素 E3 连接酶 BFAR 促进 PNPLA3 的降解。
Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2312291121. doi: 10.1073/pnas.2312291121. Epub 2024 Jan 31.
4
NAFLD and NAFLD-related HCC in Asia: Burden and Surveillance.亚洲的非酒精性脂肪性肝病及非酒精性脂肪性肝病相关肝细胞癌：负担与监测
J Clin Exp Hepatol. 2024 Jan-Feb;14(1):101213. doi: 10.1016/j.jceh.2023.06.013. Epub 2023 Jul 5.
5
Non-alcoholic fatty liver disease and socioeconomic determinants in an Iranian cohort study.伊朗队列研究中的非酒精性脂肪性肝病与社会经济决定因素。
BMC Gastroenterol. 2023 Oct 9;23(1):350. doi: 10.1186/s12876-023-02964-4.
6
Higher mortality among lean patients with non-alcoholic fatty liver disease despite fewer metabolic comorbidities.非酒精性脂肪性肝病消瘦患者的死亡率较高，尽管合并代谢性合并症较少。
Aliment Pharmacol Ther. 2023 May;57(9):1014-1027. doi: 10.1111/apt.17424. Epub 2023 Feb 23.
7
Molecular Screening via Sanger Sequencing of the Genetic Variants in Non-Alcoholic Fatty Liver Disease Subjects in the Saudi Population: A Hospital-Based Study.沙特人群非酒精性脂肪性肝病患者基因变异的桑格测序分子筛查：一项基于医院的研究
Metabolites. 2022 Dec 9;12(12):1240. doi: 10.3390/metabo12121240.
8
Association between metabolically healthy obesity and non-alcoholic fatty liver disease.代谢健康型肥胖与非酒精性脂肪性肝病的相关性。
Hepatol Int. 2022 Dec;16(6):1412-1423. doi: 10.1007/s12072-022-10395-8. Epub 2022 Aug 20.
9
rs738409 C>G Variant Influences the Association Between Visceral Fat and Significant Fibrosis in Biopsy-proven Nonalcoholic Fatty Liver Disease.rs738409 C>G变异影响经活检证实的非酒精性脂肪性肝病中内脏脂肪与显著纤维化之间的关联。
J Clin Transl Hepatol. 2022 Jun 28;10(3):439-448. doi: 10.14218/JCTH.2021.00286. Epub 2021 Oct 22.
10
Validation of genetic variants associated with metabolic dysfunction-associated fatty liver disease in an ethnic Chinese population.在中国汉族人群中验证与代谢功能障碍相关脂肪性肝病相关的基因变异
World J Hepatol. 2020 Dec 27;12(12):1228-1238. doi: 10.4254/wjh.v12.i12.1228.

本文引用的文献

1
I148M variant of PNPLA3 confer increased risk for nonalcoholic fatty liver disease not only in European population, but also in Chinese population.PNPLA3的I148M变体不仅在欧洲人群中，而且在中国人群中都增加了非酒精性脂肪性肝病的风险。
Hepatology. 2011 Dec;54(6):2275. doi: 10.1002/hep.24567.
2
Human fatty liver disease: old questions and new insights.人类脂肪肝疾病：旧问题与新见解。
Science. 2011 Jun 24;332(6037):1519-23. doi: 10.1126/science.1204265.
3
Nonalcoholic fatty liver in Asia: Firmly entrenched and rapidly gaining ground.亚洲的非酒精性脂肪性肝病：根深蒂固且迅速蔓延。
J Gastroenterol Hepatol. 2011 Jan;26 Suppl 1:163-72. doi: 10.1111/j.1440-1746.2010.06548.x.
4
Guidelines for the diagnosis and treatment of nonalcoholic fatty liver diseases.非酒精性脂肪性肝病诊疗指南
J Dig Dis. 2008 May;9(2):108-12. doi: 10.1111/j.1751-2980.2008.00331.x.
5
Metabolic syndrome and non-alcoholic fatty liver disease: Asian definitions and Asian studies.代谢综合征与非酒精性脂肪性肝病：亚洲的定义及亚洲的研究
Hepatobiliary Pancreat Dis Int. 2007 Dec;6(6):572-8.