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芳香草本植物精油作为抗菌剂。

Essential oils from aromatic herbs as antimicrobial agents.

机构信息

Medical Direction, Unidad Medica de Alta Especialidad Hospital de Pediatria, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtemoc 330 Col. Doctores, México Distrito Federal, CP 06720, Mexico.

出版信息

Curr Opin Biotechnol. 2012 Apr;23(2):136-41. doi: 10.1016/j.copbio.2011.08.005. Epub 2011 Sep 6.

Abstract

Bacterial resistance to multiple antibiotics is a health problem. Essential oils (EOs) possess antibacterial properties and have been screened as potential sources of novel antimicrobial compounds. Terpenes and terpenoids are components derived from EOs. Some of these EOs show inhibitory activity against Staphylococcus aureus. Carvacrol has specific effects on S. aureus and Staphylococcus epidermidis. Perilla oil suppresses expression of α-toxin, Staphylococcus enterotoxin A and B and toxic shock syndrome toxin. Geraniol shows good activity in modulating drug resistance in several gram-negative species. EOs could act as biopreservatives, reducing or eliminating pathogenic bacteria and increasing the overall quality of animal and vegetable food products. Although clinical studies are scarce, the uses of EOs for topical administration and as penetration enhancers for antiseptics are promising. Little information exists for oral administration.

摘要

细菌对抗多种抗生素的耐药性是一个健康问题。精油(EOs)具有抗菌特性,已被筛选为新型抗菌化合物的潜在来源。萜类化合物和萜烯类化合物是从 EOs 中衍生出来的成分。其中一些 EOs 对金黄色葡萄球菌表现出抑制活性。香芹酚对金黄色葡萄球菌和表皮葡萄球菌有特殊作用。紫苏油抑制α-毒素、肠毒素 A 和 B 以及中毒性休克综合征毒素的表达。香叶醇在调节几种革兰氏阴性菌的耐药性方面表现出良好的活性。EOs 可以作为生物防腐剂,减少或消除致病菌,提高动物和植物食品的整体质量。尽管临床研究很少,但 EOs 用于局部给药和作为防腐剂的渗透增强剂的用途很有前景。口服给药的信息很少。

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