核糖体突变是弯曲菌属（空肠弯曲菌和结肠弯曲菌）中大环内酯类耐药的主要原因。
Ribosomal mutations as the main cause of macrolide resistance in Campylobacter jejuni and Campylobacter coli.
机构信息
Antimicrobial Resistance Unit, National Institute for Health and Welfare, THL, Kiinamyllynkatu 13, 20520 Turku, Finland.
出版信息
Antimicrob Agents Chemother. 2011 Dec;55(12):5939-41. doi: 10.1128/AAC.00314-11. Epub 2011 Sep 12.
Abstract
The aim of this study was to examine macrolide resistance mutations in Campylobacter species. In 76 strains studied, point mutation A to G at position 2059 of the 23S rRNA gene was detected in 30 of the 33 erythromycin-resistant strains. An amino acid insertion in the ribosomal protein L22 was found in one resistant strain without a 23S rRNA mutation. The A2059G mutation is the main cause of macrolide resistance in Campylobacter species.
摘要
本研究旨在检测弯曲菌属中大环内酯类耐药突变。在研究的 76 株菌中，33 株红霉素耐药菌株中有 30 株检测到 23S rRNA 基因 2059 位的点突变 A 到 G。在一个没有 23S rRNA 突变的耐药菌株中发现核糖体蛋白 L22 中的氨基酸插入。A2059G 突变是弯曲菌属大环内酯类耐药的主要原因。
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