• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

核糖体突变是弯曲菌属（空肠弯曲菌和结肠弯曲菌）中大环内酯类耐药的主要原因。

Ribosomal mutations as the main cause of macrolide resistance in Campylobacter jejuni and Campylobacter coli.

机构信息

Antimicrobial Resistance Unit, National Institute for Health and Welfare, THL, Kiinamyllynkatu 13, 20520 Turku, Finland.

出版信息

Antimicrob Agents Chemother. 2011 Dec;55(12):5939-41. doi: 10.1128/AAC.00314-11. Epub 2011 Sep 12.

DOI:10.1128/AAC.00314-11
PMID:21911571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3232809/
Abstract

The aim of this study was to examine macrolide resistance mutations in Campylobacter species. In 76 strains studied, point mutation A to G at position 2059 of the 23S rRNA gene was detected in 30 of the 33 erythromycin-resistant strains. An amino acid insertion in the ribosomal protein L22 was found in one resistant strain without a 23S rRNA mutation. The A2059G mutation is the main cause of macrolide resistance in Campylobacter species.

摘要

本研究旨在检测弯曲菌属中大环内酯类耐药突变。在研究的 76 株菌中，33 株红霉素耐药菌株中有 30 株检测到 23S rRNA 基因 2059 位的点突变 A 到 G。在一个没有 23S rRNA 突变的耐药菌株中发现核糖体蛋白 L22 中的氨基酸插入。A2059G 突变是弯曲菌属大环内酯类耐药的主要原因。

相似文献

1
Ribosomal mutations as the main cause of macrolide resistance in Campylobacter jejuni and Campylobacter coli.核糖体突变是弯曲菌属（空肠弯曲菌和结肠弯曲菌）中大环内酯类耐药的主要原因。
Antimicrob Agents Chemother. 2011 Dec;55(12):5939-41. doi: 10.1128/AAC.00314-11. Epub 2011 Sep 12.
2
Macrolide resistance in Campylobacter jejuni and Campylobacter coli: molecular mechanism and stability of the resistance phenotype.空肠弯曲菌和结肠弯曲菌中的大环内酯类耐药性：耐药表型的分子机制与稳定性
Antimicrob Agents Chemother. 2005 Jul;49(7):2753-9. doi: 10.1128/AAC.49.7.2753-2759.2005.
3
23S rRNA gene mutations contributing to macrolide resistance in Campylobacter jejuni and Campylobacter coli.导致空肠弯曲菌和大肠弯曲菌对大环内酯类药物耐药的 23S rRNA 基因突变。
Foodborne Pathog Dis. 2009 Jan-Feb;6(1):91-8. doi: 10.1089/fpd.2008.0098.
4
Study of the molecular mechanisms involved in high-level macrolide resistance of Spanish Campylobacter jejuni and Campylobacter coli strains.研究西班牙空肠弯曲菌和结肠弯曲菌高水平大环内酯类耐药相关的分子机制。
J Antimicrob Chemother. 2010 Oct;65(10):2083-8. doi: 10.1093/jac/dkq268. Epub 2010 Jul 20.
5
Macrolide resistance mechanisms and virulence factors in erythromycin-resistant Campylobacter species isolated from chicken and swine feces and carcasses.从鸡和猪的粪便及尸体中分离出的耐红霉素弯曲杆菌属中的大环内酯类耐药机制及毒力因子
J Vet Med Sci. 2017 Jan 10;78(12):1791-1795. doi: 10.1292/jvms.16-0307. Epub 2016 Sep 2.
6
Rapid detection of point mutations in domain V of the 23S rRNA gene in erythromycin-resistant Campylobacter isolates by pyrosequencing.采用焦磷酸测序技术快速检测红霉素耐药弯曲菌分离株 23S rRNA 基因 V 区点突变。
Foodborne Pathog Dis. 2011 Mar;8(3):375-9. doi: 10.1089/fpd.2010.0676. Epub 2010 Dec 18.
7
Synergy between efflux pump CmeABC and modifications in ribosomal proteins L4 and L22 in conferring macrolide resistance in Campylobacter jejuni and Campylobacter coli.空肠弯曲菌和结肠弯曲菌中流出泵CmeABC与核糖体蛋白L4和L22修饰在赋予大环内酯抗性方面的协同作用。
Antimicrob Agents Chemother. 2006 Nov;50(11):3893-6. doi: 10.1128/AAC.00616-06. Epub 2006 Aug 28.
8
Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni.空肠弯曲杆菌中大环内酯类耐药性的产生、稳定性及分子机制
Antimicrob Agents Chemother. 2008 Nov;52(11):3947-54. doi: 10.1128/AAC.00450-08. Epub 2008 Sep 8.
9
MAMA-PCR assay for the detection of point mutations associated with high-level erythromycin resistance in Campylobacter jejuni and Campylobacter coli strains.用于检测空肠弯曲菌和结肠弯曲菌菌株中与高水平红霉素耐药相关点突变的MAMA-PCR检测法。
J Microbiol Methods. 2005 Oct;63(1):99-103. doi: 10.1016/j.mimet.2005.03.013.
10
Rapid detection of mutations associated with resistance to erythromycin in Campylobacter jejuni/coli by PCR and line probe assay.通过聚合酶链反应（PCR）和线性探针分析快速检测空肠弯曲菌/结肠弯曲菌中与红霉素耐药相关的突变
Int J Antimicrob Agents. 2001 Oct;18(4):359-64. doi: 10.1016/s0924-8579(01)00425-3.

引用本文的文献

1
Sharing of alleles between and associated with extensive drug resistance in isolates from infants and poultry in the Peruvian Amazon.秘鲁亚马逊地区婴儿和家禽分离株中与广泛耐药相关的[具体细菌名称未给出]之间等位基因的共享情况。 （注：原文中“and”连接的两个内容缺失，翻译时根据语境补充了“[具体细菌名称未给出]”使句子完整表意，但实际翻译需根据完整准确的原文进行）
mBio. 2025 Feb 5;16(2):e0205424. doi: 10.1128/mbio.02054-24. Epub 2024 Dec 27.
2
Long non-coding RNAs as the critical regulators of PI3K/AKT, TGF-β, and MAPK signaling pathways during breast tumor progression.长非编码 RNA 作为 PI3K/AKT、TGF-β 和 MAPK 信号通路在乳腺癌进展过程中的关键调节因子。
J Transl Med. 2023 Aug 18;21(1):556. doi: 10.1186/s12967-023-04434-7.
3
Antibiotic Resistance in Bacteria-A Review.细菌中的抗生素耐药性——综述
Antibiotics (Basel). 2022 Aug 9;11(8):1079. doi: 10.3390/antibiotics11081079.
4
The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression Controlling the TGF-β Signaling Pathway.长链非编码RNA ADAMTS9-AS2通过调控核糖体蛋白L22来调节三阴性乳腺癌进展并控制转化生长因子-β信号通路。
Front Oncol. 2021 Jun 9;11:654472. doi: 10.3389/fonc.2021.654472. eCollection 2021.
5
Antimicrobial Resistance Profiles and Macrolide Resistance Mechanisms of Isolated from Pigs and Chickens.从猪和鸡中分离出的抗菌药物耐药谱及大环内酯类耐药机制
Microorganisms. 2021 May 17;9(5):1077. doi: 10.3390/microorganisms9051077.
6
Antibiotic Resistance Profiles and Molecular Mechanisms of From Chicken and Pig in China.中国鸡和猪源的抗生素耐药谱及分子机制
Front Microbiol. 2020 Oct 27;11:592496. doi: 10.3389/fmicb.2020.592496. eCollection 2020.
7
Prediction of antimicrobial resistance in clinical Campylobacter jejuni isolates from whole-genome sequencing data.基于全基因组测序数据预测临床空肠弯曲菌分离株的抗菌药物耐药性。
Eur J Clin Microbiol Infect Dis. 2021 Apr;40(4):673-682. doi: 10.1007/s10096-020-04043-y. Epub 2020 Sep 24.
8
WGS-Based Prediction and Analysis of Antimicrobial Resistance in Isolates From Israel.基于全基因组测序的以色列分离株抗菌药物耐药性预测与分析
Front Cell Infect Microbiol. 2020 Aug 13;10:365. doi: 10.3389/fcimb.2020.00365. eCollection 2020.
9
Antimicrobial resistance in enteric bacteria: current state and next-generation solutions.肠道细菌的抗药性：现状和下一代解决方案。
Gut Microbes. 2020 Nov 9;12(1):1799654. doi: 10.1080/19490976.2020.1799654.
10
Molecular Basis of Macrolide Resistance in Strains Isolated from Poultry in South Korea.韩国家禽分离株中大环内酯类耐药的分子基础。
Biomed Res Int. 2018 Jul 5;2018:4526576. doi: 10.1155/2018/4526576. eCollection 2018.

本文引用的文献

1
In vitro activity of azithromycin against nontyphoidal Salmonella enterica.阿奇霉素对非伤寒沙门氏菌的体外活性。
Antimicrob Agents Chemother. 2010 Aug;54(8):3498-501. doi: 10.1128/AAC.01678-09. Epub 2010 May 24.
2
Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents.多重耐药空肠弯曲菌和结肠弯曲菌菌株的抗菌药敏性：20 种抗菌药物的体外活性。
Antimicrob Agents Chemother. 2010 Mar;54(3):1232-6. doi: 10.1128/AAC.00898-09. Epub 2009 Dec 28.
3
Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni.空肠弯曲杆菌中大环内酯类耐药性的产生、稳定性及分子机制
Antimicrob Agents Chemother. 2008 Nov;52(11):3947-54. doi: 10.1128/AAC.00450-08. Epub 2008 Sep 8.
4
Effect of putative efflux pump inhibitors and inducers on the antimicrobial susceptibility of Campylobacter jejuni and Campylobacter coli.推测的外排泵抑制剂和诱导剂对空肠弯曲菌和结肠弯曲菌抗菌药敏性的影响。
J Med Microbiol. 2008 Jul;57(Pt 7):851-855. doi: 10.1099/jmm.0.47823-0.
5
Correct identification and discrimination between Campylobacter jejuni and C. coli by a standardized hippurate test and species-specific polymerase chain reaction.通过标准化马尿酸盐试验和种特异性聚合酶链反应对空肠弯曲菌和结肠弯曲菌进行正确鉴定和区分。
Eur J Clin Microbiol Infect Dis. 2008 Jul;27(7):513-8. doi: 10.1007/s10096-008-0467-9. Epub 2008 Mar 4.
6
Novel mutations in ribosomal proteins L4 and L22 that confer erythromycin resistance in Escherichia coli.核糖体蛋白L4和L22中的新型突变赋予大肠杆菌红霉素抗性。
Mol Microbiol. 2007 Nov;66(4):1039-50. doi: 10.1111/j.1365-2958.2007.05975.x. Epub 2007 Oct 22.
7
Synergy between efflux pump CmeABC and modifications in ribosomal proteins L4 and L22 in conferring macrolide resistance in Campylobacter jejuni and Campylobacter coli.空肠弯曲菌和结肠弯曲菌中流出泵CmeABC与核糖体蛋白L4和L22修饰在赋予大环内酯抗性方面的协同作用。
Antimicrob Agents Chemother. 2006 Nov;50(11):3893-6. doi: 10.1128/AAC.00616-06. Epub 2006 Aug 28.
8
Macrolide resistance in Campylobacter jejuni and Campylobacter coli.空肠弯曲菌和结肠弯曲菌中的大环内酯类耐药性。
J Antimicrob Chemother. 2006 Aug;58(2):243-55. doi: 10.1093/jac/dkl210. Epub 2006 May 30.
9
An investigation of the molecular mechanisms contributing to high-level erythromycin resistance in Campylobacter.对弯曲杆菌中高水平红霉素耐药性分子机制的研究。
Int J Antimicrob Agents. 2006 Jan;27(1):40-5. doi: 10.1016/j.ijantimicag.2005.08.019. Epub 2005 Nov 28.
10
Macrolide resistance in Campylobacter jejuni and Campylobacter coli: molecular mechanism and stability of the resistance phenotype.空肠弯曲菌和结肠弯曲菌中的大环内酯类耐药性：耐药表型的分子机制与稳定性
Antimicrob Agents Chemother. 2005 Jul;49(7):2753-9. doi: 10.1128/AAC.49.7.2753-2759.2005.