Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.
J Leukoc Biol. 2011 Dec;90(6):1079-87. doi: 10.1189/jlb.0611271. Epub 2011 Sep 13.
CD4(+) T cells, which express a master transcription factor, Foxp3, have been recognized as bona fide Tregs. These cells are essential to maintain immune homeostasis in healthy as well as infected mice and humans. Extensive investigations in the last decade have provided ways to manipulate the Foxp3(+) Treg response therapeutically so the role of such cells in microbe-induced inflammatory reactions can be evaluated. This review focuses on our current understanding of the mechanisms required for the generation and sustenance of Tregs in vivo and the potential value of modulating Tregs to control microbe-induced immunopathological responses.
CD4(+) T 细胞表达一种主转录因子 Foxp3，已被确认为真正的调节性 T 细胞。这些细胞对于维持健康以及感染小鼠和人类的免疫内稳态至关重要。在过去十年的广泛研究中，已经提供了一些方法来对 Foxp3(+)Treg 反应进行治疗性操纵，以便评估这些细胞在微生物诱导的炎症反应中的作用。本综述重点介绍了我们目前对体内 Treg 产生和维持所需机制的理解，以及调节 Treg 控制微生物诱导的免疫病理反应的潜在价值。
