Department of Psychology, Harvard University, Cambridge, MA, USA.
Soc Cogn Affect Neurosci. 2012 Oct;7(7):794-803. doi: 10.1093/scan/nsr054. Epub 2011 Sep 14.
Prior neuroimaging and electrophysiological evidence suggests that potentiated responses in the anterior cingulate cortex (ACC), particularly the rostral ACC, may contribute to abnormal responses to negative feedback in individuals with elevated negative affect and depressive symptoms. The feedback-related negativity (FRN) represents an electrophysiological index of ACC-related activation in response to performance feedback. The purpose of the present study was to examine the FRN and underlying ACC activation using low resolution electromagnetic tomography source estimation techniques in relation to negative emotionality (a composite index including negative affect and subclinical depressive symptoms). To this end, 29 healthy adults performed a monetary incentive delay task while 128-channel event-related potentials were recorded. We found that enhanced FRNs and increased rostral ACC activation in response to negative--but not positive--feedback was related to greater negative emotionality. These results indicate that individual differences in negative emotionality--a putative risk factor for emotional disorders--modulate ACC-related processes critically implicated in assessing the motivational impact and/or salience of environmental feedback.
先前的神经影像学和电生理学证据表明，前扣带皮层（ACC）中增强的反应，特别是额前 ACC，可能导致对具有升高的消极情绪和抑郁症状的个体的负面反馈有异常反应。反馈相关负波（FRN）是对性能反馈的 ACC 相关激活的电生理指数。本研究的目的是使用低分辨率电磁层析源估计技术，检查 FRN 和相关的 ACC 激活与负性情绪（包括消极情绪和亚临床抑郁症状的综合指数）的关系。为此，29 名健康成年人在执行货币奖励延迟任务时记录了 128 通道事件相关电位。我们发现，对负性反馈而不是正性反馈的增强的 FRN 和额前 ACC 激活与更大的负性情绪有关。这些结果表明，负性情绪的个体差异——一种情绪障碍的潜在风险因素——调节了在评估环境反馈的动机影响和/或显著性方面至关重要的 ACC 相关过程。
