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感觉刺激阈值是否会影响腰椎小关节射频神经切断术的疗效?一项前瞻性临床相关性研究。

Does sensory stimulation threshold affect lumbar facet radiofrequency denervation outcomes? A prospective clinical correlational study.

机构信息

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, 550 North Broadway, Suite 301, Baltimore, MD 21029, USA.

出版信息

Anesth Analg. 2011 Nov;113(5):1233-41. doi: 10.1213/ANE.0b013e31822dd379. Epub 2011 Sep 14.

Abstract

BACKGROUND

Radiofrequency facet denervation is one of the most frequently performed procedures for chronic low back pain. Although sensory stimulation is generally used as a surrogate measure to denote sufficient proximity of the electrode to the nerve, no study has examined whether stimulation threshold influences outcome.

METHODS

We prospectively recorded data in 61 consecutive patients undergoing lumbar facet radiofrequency denervation who experienced significant pain relief after medial branch blocks. For each nerve lesioned, multiple attempts were made to maximize sensory stimulation threshold (SST). Mean SST was calculated on the basis of the lowest stimulation perceived at 0.1-V increments for each medial branch. A positive outcome was defined as a ≥50% reduction in back pain coupled with a positive satisfaction score lasting ≥3 months. The relationship between mean SST and denervation outcomes was evaluated via a receiver's operating characteristic (ROC) curve, and stratifying outcomes on the basis of various cutoff values.

RESULTS

No correlation was noted between mean SST and pain relief at rest (Pearson's r=-0.01, 95% confidence interval [CI]: -0.24 to 0.23, P=0.97), with activity (r=-0.17, 95% CI: -0.40 to 0.07, P=0.20), or a successful outcome. No optimal SST could be identified.

CONCLUSIONS

There is no significant relationship between mean SST during lumbar facet radiofrequency denervation and treatment outcome, which may be due to differences in general sensory perception. Because stimulation threshold was optimized for each patient, these data cannot be interpreted to suggest that sensory testing should not be performed, or that high sensory stimulation thresholds obtained on the first attempt should be deemed acceptable.

摘要

背景

射频关节突神经消融术是治疗慢性下腰痛最常用的方法之一。尽管感觉刺激通常被用作表示电极与神经足够接近的替代测量方法,但尚无研究检查刺激阈值是否会影响结果。

方法

我们前瞻性地记录了 61 例接受腰椎关节突射频消融术的连续患者的数据,这些患者在接受内侧支阻滞后经历了明显的疼痛缓解。对于每个受损的神经,我们多次尝试最大程度地提高感觉刺激阈值(SST)。根据每个内侧支的 0.1-V 增量感知到的最低刺激来计算平均 SST。阳性结果定义为背部疼痛减轻≥50%,同时满意度评分≥3 个月。通过接收者操作特征(ROC)曲线评估平均 SST 与神经消融结果之间的关系,并根据各种截止值对结果进行分层。

结果

平均 SST 与静息时的疼痛缓解之间没有相关性(Pearson r=-0.01,95%置信区间[CI]:-0.24 至 0.23,P=0.97),与活动时的疼痛缓解(r=-0.17,95% CI:-0.40 至 0.07,P=0.20)或成功结果也没有相关性。无法确定最佳的 SST。

结论

在腰椎关节突射频消融术中,平均 SST 与治疗结果之间没有显著关系,这可能是由于一般感觉感知的差异所致。由于为每个患者优化了刺激阈值,因此不能将这些数据解释为表明不应进行感觉测试,或者首次获得的高感觉刺激阈值应被视为可接受的。

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