Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Georgia, USA.
School of Electrical and Computer Engineering, Georgia Institute of Technology, Georgia, USA.
Theranostics. 2022 Jan 24;12(4):1783-1799. doi: 10.7150/thno.54056. eCollection 2022.
Superparamagnetic nanoparticles have become an important tool in biomedicine. Their biocompatibility, controllable small size, and magnetic properties allow manipulation with an external magnetic field for a variety of diagnostic and therapeutic applications. Recently, the magnetically-induced motion of superparamagnetic nanoparticles has been investigated as a new source of imaging contrast. In magneto-motive imaging, an external, time-varying magnetic field is applied to move a magnetically labeled subject, such as labeled cells or tissue. Several major imaging modalities such as ultrasound, photoacoustic imaging, optical coherence tomography, and laser speckle tracking can utilize magneto-motive contrast to monitor biological events at smaller scales with enhanced contrast and sensitivity. In this review article, an overview of magneto-motive imaging techniques is presented, including synthesis of superparamagnetic nanoparticles, fundamental principles of magneto-motive force and its utility to excite labeled tissue within a viscoelastic medium, current capabilities of magneto-motive imaging modalities, and a discussion of the challenges and future outlook in the magneto-motive imaging domain.
超顺磁纳米颗粒在生物医学领域已经成为一种重要的工具。其具有良好的生物相容性、可控制的小尺寸以及磁特性，可在外磁场的作用下进行操控，从而实现多种诊断和治疗应用。最近，超顺磁纳米颗粒的磁致运动已被研究作为一种新的成像对比源。在磁激励成像中，施加外部时变磁场以移动磁性标记的对象，例如标记的细胞或组织。几种主要的成像模式，如超声、光声成像、光学相干断层扫描和激光散斑跟踪，都可以利用磁激励对比度以更高的对比度和灵敏度来监测更小尺度的生物事件。在这篇综述文章中，介绍了磁激励成像技术的概述，包括超顺磁纳米颗粒的合成、磁激励力的基本原理及其在粘弹性介质中激发标记组织的应用、磁激励成像模式的当前能力，以及在磁激励成像领域的挑战和未来展望的讨论。
