Bilchik A J, Leach S D, Zucker K A, Modlin I M
Department of Surgery, Yale University School of Medicine, New Haven, Connecticut.
J Surg Res. 1990 Jun;48(6):639-47. doi: 10.1016/0022-4804(90)90245-w.
Acute pancreatitis remains a disease of uncertain pathogenesis and nonspecific therapy. Because of the practical problems plaguing investigation of pancreatitis in man, investigators have developed various experimental animal models of pancreatitis in order to develop rationale concepts regarding pathogenesis and therapy. Despite numerous investigations over the past century, the events involved in the initiation and progression of pancreatitis remain obscure. Indeed, identification of the cellular mechanisms responsible for the initiation of this disease may allow for significant advances in therapy. Previous studies have largely focused on the mechanism of pancreatitis at the organ level. It is now apparent that the early initiating events in acute pancreatitis probably occur at a membrane or intracellular level. The resolution of the cellular events which underlie the development of pancreatitis in combination with the introduction of new therapeutic agents may enable a rational and safe protocol to be developed for the support of patients with pancreatitis. In this review different experimental models of acute pancreatitis are discussed. Emphasis is placed on the relevance of various models to clinical pancreatitis.
急性胰腺炎仍然是一种发病机制不明且治疗方法缺乏特异性的疾病。由于困扰人类胰腺炎研究的实际问题，研究人员开发了各种胰腺炎实验动物模型，以便形成关于发病机制和治疗的合理概念。尽管在过去一个世纪进行了大量研究，但胰腺炎发生和发展过程中涉及的事件仍然不清楚。事实上，确定引发这种疾病的细胞机制可能会使治疗取得重大进展。以前的研究主要集中在器官水平的胰腺炎机制上。现在很明显，急性胰腺炎早期引发事件可能发生在细胞膜或细胞内水平。结合新治疗药物的引入，解决胰腺炎发展背后的细胞事件，可能会制定出合理且安全的方案来支持胰腺炎患者。本文综述了不同的急性胰腺炎实验模型。重点讨论了各种模型与临床胰腺炎的相关性。
