Apoptosis Research Group, School of Medical Science, Griffith University Gold Coast Campus, Southport, 4222 Qld, Australia.
Cell Res. 2012 Feb;22(2):285-7. doi: 10.1038/cr.2011.160. Epub 2011 Sep 27.
It is well documented that the oncogene efficiently transforms non-malignant cells, and there is some evidence for the role of mitochondria in this process. Now Peng Huang and colleagues show that K-Ras induction results early on in mitochondria assuming the phenotype consistent with the so-called Warburg effect, i.e., increased glycolysis and attenuated oxidative phosphorylation. Thus the K-Ras protein capable of swift induction of phenotypic changes typical of cancer cells, yet these changes are reversible, and for cells to irreversibly reach their full malignant potential a much longer K-Ras expression is required, implicating mitochondria in the longer-term effects of the oncogene.
有大量文献记载表明癌基因能够有效地转化非恶性细胞，并且有一些证据表明线粒体在这个过程中起作用。现在，Peng Huang 和他的同事们表明，K-Ras 的诱导导致线粒体早期表现出与所谓的Warburg 效应一致的表型，即增加糖酵解和减弱氧化磷酸化。因此，K-Ras 蛋白能够迅速诱导类似于癌细胞的表型变化，但这些变化是可逆的，而细胞要不可逆地达到其完全恶性的潜力，则需要更长时间的 K-Ras 表达，这表明线粒体参与了癌基因的长期效应。
