Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, MA 02215, USA.
Angew Chem Int Ed Engl. 2011 Oct 4;50(41):9722-6. doi: 10.1002/anie.201104504. Epub 2011 Aug 30.
[Image: see text] An asymmetric total synthesis of the epoxykinamycin FL-120B’ is reported. The synthesis establishes a route to epoxide-containing diazobenzofluorenes which could potentially serve as monomers to the dimeric lomaiviticins. Key steps include Sharpless asymmetric epoxidation, Stille coupling, and intramolecular Friedel-Crafts acylation of atropisomeric carboxylic acids at elevated temperatures to construct the FL-120B’ core structure.
[图片：见正文] 本文报道了环氧金霉素 FL-120B' 的不对称全合成。该合成方法建立了一种含环氧基二氮杂苯并菲的合成路线，这些化合物可能作为二聚洛马维丁的单体。关键步骤包括 Sharpless 不对称环氧化、Stille 偶联以及在高温下对非对映异构体羧酸进行分子内 Friedel-Crafts 酰化，以构建 FL-120B' 的核心结构。
