Rapid Response Radiotherapy Program, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Expert Rev Pharmacoecon Outcomes Res. 2011 Oct;11(5):541-7. doi: 10.1586/erp.11.64.
Shorter quality-of-life (QoL) assessments are beneficial for palliative patients as they reduce burden associated with completing personal, and at times stressful, questionnaires. The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 Palliative (QLQ-C15-PAL) and the Functional Assessment of Chronic Illness Therapy - Palliative Care (FACIT-Pal) are two palliative QoL tools that have been validated for use in this population. The purpose of this article was to conduct a review of studies utilizing these two palliative-specific QoL instruments, their development and their relative strengths for use in advanced cancer patients. Studies detailing the development process for the QLQ-C15-PAL and the FACIT-Pal were identified. A comparison between both questionnaires in terms of development, characteristics, validation and use was conducted. The QLQ-C15-PAL was developed via structured shortening of the longer core instrument, the Quality of Life Questionnaire Core 30 (QLQ-C30), whereas the FACIT-Pal includes the Functional Assessment of Cancer Therapy - General tool plus a new 19-item palliative scale created through interviews with patients and healthcare professionals. Although significant overlap exists between both tools, there is a marked difference in the aspects of QoL assessed. Scoring, organization and item format are different; however, response options and recall period are the same. Both tools cover the core items relevant to patients with advanced cancers and can be supplemented with disease-specific tools. Both QLQ-C15-PAL and FACIT-Pal allow for assessment of QoL issues specific to patients with advanced diseases. Each instrument has unique strengths and weaknesses and choice between these tools is dependent on the investigator and study needs. Future studies should directly compare these two tools and validate their use through a number of administration modes.
较短的生活质量（QoL）评估对姑息治疗患者有益，因为它们减轻了完成个人问卷的负担，有时甚至是压力。欧洲癌症研究与治疗组织的生活质量问卷核心 15 姑息治疗（QLQ-C15-PAL）和慢性疾病治疗功能评估 - 姑息治疗（FACIT-Pal）是两种已被验证可用于该人群的姑息治疗 QoL 工具。本文旨在对使用这两种姑息治疗特定 QoL 工具的研究进行综述，包括它们的开发及其在晚期癌症患者中的相对优势。确定了详细描述 QLQ-C15-PAL 和 FACIT-Pal 开发过程的研究。对这两个问卷在开发、特征、验证和使用方面进行了比较。QLQ-C15-PAL 是通过对较长的核心仪器，即生活质量问卷核心 30（QLQ-C30）进行结构化缩短而开发的，而 FACIT-Pal 包括功能评估癌症治疗 - 一般工具，以及通过对患者和医疗保健专业人员的访谈创建的新的 19 项姑息量表。尽管两个工具之间存在显著的重叠，但评估的 QoL 方面存在明显的差异。评分、组织和项目格式不同；但是，回答选项和回忆期是相同的。这两个工具都涵盖了与晚期癌症患者相关的核心项目，并且可以与疾病特异性工具一起补充。QLQ-C15-PAL 和 FACIT-Pal 都可以评估晚期疾病患者的特定 QoL 问题。每个工具都有独特的优势和劣势，并且这些工具的选择取决于研究者和研究需求。未来的研究应该直接比较这两种工具，并通过多种管理模式验证其使用。
