Vasil'eva I G, Drozdov S G, Sdirkova N I
Vopr Virusol. 1979 Mar-Apr(2):165-9.
Adaptation of poliomyelitis virus type I (Mahoney strain) to the CNS of cotton rats which at the time of inoculation had been temporarily immunosuppressed with cyclophosphane is described. In the course of passages the virus properties were observed to change. The virus became pathogenic for cotton rats with normal immunologic responsiveness by the intracerebral, intraperitoneal and subcutaneous routes, as well as for white mice intracerebrally. Virions pathogenic for cotton rats were predominant in the adapted strain population.
描述了I型脊髓灰质炎病毒（马奥尼株）对棉鼠中枢神经系统的适应性，这些棉鼠在接种时已用环磷酰胺进行了暂时免疫抑制。在传代过程中观察到病毒特性发生了变化。该病毒通过脑内、腹腔内和皮下途径对具有正常免疫反应性的棉鼠以及对脑内接种的小白鼠具有致病性。在适应株群体中，对棉鼠具有致病性的病毒粒子占主导地位。
