Department of Biomedical Engineering, Division of Imaging Sciences and Biomedical Engineering, King's College London, UK.
Philos Trans A Math Phys Eng Sci. 2011 Nov 13;369(1954):4331-51. doi: 10.1098/rsta.2011.0139.
Ongoing developments in cardiac modelling have resulted, in particular, in the development of advanced and increasingly complex computational frameworks for simulating cardiac tissue electrophysiology. The goal of these simulations is often to represent the detailed physiology and pathologies of the heart using codes that exploit the computational potential of high-performance computing architectures. These developments have rapidly progressed the simulation capacity of cardiac virtual physiological human style models; however, they have also made it increasingly challenging to verify that a given code provides a faithful representation of the purported governing equations and corresponding solution techniques. This study provides the first cardiac tissue electrophysiology simulation benchmark to allow these codes to be verified. The benchmark was successfully evaluated on 11 simulation platforms to generate a consensus gold-standard converged solution. The benchmark definition in combination with the gold-standard solution can now be used to verify new simulation codes and numerical methods in the future.
心脏建模的持续发展，特别是在模拟心脏组织电生理学的先进且日益复杂的计算框架方面取得了进展。这些模拟的目标通常是使用利用高性能计算架构计算潜力的代码来表示心脏的详细生理学和病理学。这些发展迅速提高了心脏虚拟生理人模型的模拟能力;然而，这也使得验证给定代码是否忠实地表示所声称的控制方程和相应的求解技术变得越来越具有挑战性。本研究提供了第一个心脏组织电生理学模拟基准，以允许对这些代码进行验证。该基准在 11 个模拟平台上成功进行了评估，生成了一致的黄金标准收敛解。该基准定义与黄金标准解相结合，现在可用于未来验证新的模拟代码和数值方法。
