Charité Universitätsmedizin Berlin, Zentrum für Muskel- und Knochenforschung, Hindenburgdamm, Berlin, Germany.
Spine (Phila Pa 1976). 2012 Jun 15;37(14):1245-51. doi: 10.1097/BRS.0b013e3182354d84.
Prospective longitudinal study.
To evaluate the recovery of the lumbar intervertebral discs after bed rest.
Prolonged bed rest is a useful model to understand the modeling and remodeling of tissues due to disuse and reloading, yet this process in the lumbar intervertebral discs has not been examined in detail.
A total of 24 male subjects completed 60 days of head-down tilt bed rest as part of the 2nd Berlin BedRest Study and returned for magnetic resonance scanning 180 days (n = 22) and 2 years (n = 21) after bed rest. Lumbar disc volume, anterior and posterior disc height, disc signal intensity, intervertebral length, and lordosis were measured on sagittal plane magnetic resonance images. RESULTS.: Compared with prior to bed rest, increases in disc volume, disc height, and intervertebral length persisted 180 days (P ≤ 0.0004) and 720 days (P ≤ 0.024) after bed rest. Disc signal intensity remained increased 180 days (P = 0.034) after bed rest but was then decreased (P = 0.018) compared with baseline at the next measurement date.
The recovery of the lumbar intervertebral discs after 60-day bed rest is a prolonged process and incomplete within 2 years.
前瞻性纵向研究。
评估卧床休息后腰椎间盘的恢复情况。
长时间卧床休息是一种有用的模型，可以了解由于停用和重新加载而导致的组织建模和重塑过程，但尚未详细研究腰椎间盘的这一过程。
共有 24 名男性受试者完成了第 2 届柏林卧床休息研究的 60 天头低位倾斜卧床休息，其中 22 名受试者在卧床休息后 180 天和 2 年进行了磁共振扫描，21 名受试者返回进行了磁共振扫描。在矢状面磁共振图像上测量腰椎间盘体积、前后椎间盘高度、椎间盘信号强度、椎间长度和脊柱前凸。
与卧床休息前相比，椎间盘体积、椎间盘高度和椎间长度的增加持续到卧床休息后 180 天（P ≤ 0.0004）和 720 天（P ≤ 0.024）。卧床休息后 180 天，椎间盘信号强度仍保持升高（P = 0.034），但在下一次测量时与基线相比降低（P = 0.018）。
60 天卧床休息后腰椎间盘的恢复是一个漫长的过程，2 年内仍未完全恢复。
