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通过自动识别混沌和振荡动力态来设计有吸引力的模型。

Designing attractive models via automated identification of chaotic and oscillatory dynamical regimes.

机构信息

Centre for Bioinformatics, Imperial College London, London SW7 2AZ, UK.

出版信息

Nat Commun. 2011 Oct 4;2:489. doi: 10.1038/ncomms1496.

DOI:10.1038/ncomms1496
PMID:21971504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3207206/
Abstract

Chaos and oscillations continue to capture the interest of both the scientific and public domains. Yet despite the importance of these qualitative features, most attempts at constructing mathematical models of such phenomena have taken an indirect, quantitative approach, for example, by fitting models to a finite number of data points. Here we develop a qualitative inference framework that allows us to both reverse-engineer and design systems exhibiting these and other dynamical behaviours by directly specifying the desired characteristics of the underlying dynamical attractor. This change in perspective from quantitative to qualitative dynamics, provides fundamental and new insights into the properties of dynamical systems.

摘要

混沌和振荡继续引起科学界和公众的兴趣。然而,尽管这些定性特征很重要,但大多数构建此类现象的数学模型的尝试都采取了间接的定量方法,例如,通过将模型拟合到有限数量的数据点。在这里,我们开发了一个定性推理框架,通过直接指定基础动态吸引子的所需特性,允许我们对表现出这些和其他动态行为的系统进行反向工程和设计。这种从定量动态到定性动态的视角转变,为动态系统的特性提供了基本的和新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d44a/3207206/3036f2f3f7a5/ncomms1496-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d44a/3207206/4fc1c3f8ce35/ncomms1496-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d44a/3207206/056c5563fae1/ncomms1496-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d44a/3207206/3036f2f3f7a5/ncomms1496-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d44a/3207206/4fc1c3f8ce35/ncomms1496-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d44a/3207206/056c5563fae1/ncomms1496-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d44a/3207206/3036f2f3f7a5/ncomms1496-f3.jpg

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1
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2
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Bioinformatics. 2010 Jan 1;26(1):104-10. doi: 10.1093/bioinformatics/btp619. Epub 2009 Oct 29.
3
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PLoS One. 2017 Jun 23;12(6):e0179507. doi: 10.1371/journal.pone.0179507. eCollection 2017.
4
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Sci Rep. 2017 Jan 9;7:40152. doi: 10.1038/srep40152.
5
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Cell Rep. 2016 Jun 14;15(11):2524-35. doi: 10.1016/j.celrep.2016.05.024. Epub 2016 Jun 2.
6
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7
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Nat Protoc. 2014 Feb;9(2):439-56. doi: 10.1038/nprot.2014.025. Epub 2014 Jan 23.
8
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Interface Focus. 2012 Apr 6;2(2):156-69. doi: 10.1098/rsfs.2011.0103. Epub 2012 Feb 1.
9
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PLoS Comput Biol. 2013;9(1):e1002888. doi: 10.1371/journal.pcbi.1002888. Epub 2013 Jan 31.
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J R Soc Interface. 2009 Aug 6;6 Suppl 4(Suppl 4):S405-17. doi: 10.1098/rsif.2009.0035.focus. Epub 2009 Apr 1.
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5
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6
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J Immunol. 2008 Dec 15;181(12):8189-93. doi: 10.4049/jimmunol.181.12.8189.
7
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J Theor Biol. 2008 Oct 21;254(4):784-98. doi: 10.1016/j.jtbi.2008.07.013. Epub 2008 Jul 22.
8
Parameter inference for biochemical systems that undergo a Hopf bifurcation.经历霍普夫分岔的生化系统的参数推断。
Biophys J. 2008 Jul;95(2):540-9. doi: 10.1529/biophysj.107.126086. Epub 2008 May 2.
9
Bayesian ranking of biochemical system models.生化系统模型的贝叶斯排序
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