Department of Chest Medicine, Hôpital du Sacré-Cœur, Université de Montréal, 5400 West Gouin Boulevard, Montreal H4J 1C5, Canada.
Immunol Allergy Clin North Am. 2011 Nov;31(4):645-62, v. doi: 10.1016/j.iac.2011.07.003.
The workplace can trigger or induce asthma and cause the onset of different types of work-related asthma (WRA). Based on current knowledge of clinical features, pathophysiologic mechanisms, and evidence supporting a causal relationship, the following conditions should be distinguished in the spectrum of WRA: (1) immunologic occupational asthma (OA), (2) nonimmunologic OA, (3) work-exacerbated asthma, and (4) variant syndromes, including eosinophilic bronchitis, potroom asthma, and asthmalike disorders caused by organic dusts. The rationale, issues, and controversies relating to this approach are critically reviewed to stimulate the development of a consensus on operational definitions of the various phenotypes of WRA.
工作场所可能引发或导致哮喘，并导致不同类型的职业性哮喘（WRA）发作。基于目前对临床特征、病理生理机制和因果关系证据的了解，应在 WRA 谱中区分以下情况：（1）免疫性职业性哮喘（OA），（2）非免疫性 OA，（3）工作加重性哮喘，和（4）变异综合征，包括嗜酸性支气管炎、铸造车间哮喘和有机粉尘引起的哮喘样疾病。对这种方法的原理、问题和争议进行了批判性审查，以激发对 WRA 各种表型的操作定义达成共识。
