School of Food Technology and Nutrition, Chonnam National University, Yeosu 550-749, Republic of Korea.
Immunopharmacol Immunotoxicol. 2012 Jun;34(3):379-84. doi: 10.3109/08923973.2011.608683. Epub 2011 Oct 8.
Arisaema cum Bile is widely used as a folk medicine in Korea. However, the systematic biological properties of Arisaema cum Bile have seldom been addressed. In this study, we evaluated the anti-inflammatory activity of Arisaema cum Bile extract on lipopolysaccharide (LPS)-induced inflammation in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages. The Arisaema cum Bile extract markedly inhibited the production of pro-inflammatory cytokines including interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, and also suppressed the mRNA and protein expressions of these cytokines. Furthermore, the Arisaema cum Bile extract also inhibited LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein and gene expressions in PMA-differentiaed THP-1 macrophages. These results suggest that Arisaema cum Bile extract may have potential for development into an effective anti-inflammatory agent, and/or as an ingredient of functional foods.
天南星在韩国被广泛用作民间药物。然而，天南星的系统生物学特性很少被提及。在这项研究中，我们评估了天南星提取物对佛波醇 12-肉豆蔻酸 13-乙酸酯（PMA）分化的 THP-1 巨噬细胞中脂多糖（LPS）诱导的炎症的抗炎活性。天南星提取物明显抑制了包括白细胞介素（IL）-1β、IL-6 和肿瘤坏死因子（TNF）-α在内的促炎细胞因子的产生，并且还抑制了这些细胞因子的 mRNA 和蛋白表达。此外，天南星提取物还抑制了 LPS 诱导的 PMA 分化的 THP-1 巨噬细胞中诱导型一氧化氮合酶（iNOS）和环氧化酶-2（COX-2）蛋白和基因表达。这些结果表明，天南星提取物可能具有开发成为有效抗炎剂的潜力，和/或作为功能性食品的成分。
