Université Paris Descartes, Assistance Publique-Hôpitaux de Paris, Hôtel-Dieu, Paris, France.
Fertil Steril. 2011 Dec;96(6):1445-50. doi: 10.1016/j.fertnstert.2011.09.010. Epub 2011 Oct 6.
To evaluate the remodeling of large arteries according to age at menopause, duration of menopause, and use of hormone therapy (HT).
A cross-sectional study consisting of baseline measurements of a multicentric randomized trial were used to evaluate arterial parameters.
The study was conducted in France, Belgium, and the Netherlands in academic hospitals and private clinics.
PATIENT(S): Postmenopausal women (n = 538) with mild hypercholesterolemia.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Common carotid artery intima-media thickness (CCA-IMT), central pulse pressure, and aortic stiffness (carotid-femoral pulse wave velocity) were measured and centrally controlled for quality. Multivariate regression analysis was used to assess the possible covariates associated with arterial parameters.
RESULT(S): Women were 58 ± 6 (mean ± SD) years of age with an age of 50 ± 5 at menopause and a mean duration of menopause of 8 ± 7 years. Lower age at menopause, time since menopause, and absence of HT use were independently associated with worsening of the arterial parameters. After multivariate analysis, HT was associated with a lower CCA-IMT (-40 μm [range -64 to -1]), whereas lower age at menopause and menopause duration were respectively associated with a CCA-IMT increase (25 μm/5 y and 27 μm/5 y). Similarly, values of central pulse pressure and pulse wave velocity were lower in HT users (-3.1 mm Hg [-5.1 to -0.9] and -0.31 m/s [-0.63 to -0.02], respectively) but worsened with age at menopause and menopause duration.
CONCLUSION(S): The age at menopause, the time since menopause, and the use of HT are independently associated with the thickening and stiffening of the large arteries.
NCT00163163.
评估绝经年龄、绝经持续时间和激素治疗（HT）对大动脉重构的影响。
使用多中心随机试验的基线测量值进行的横断面研究，用于评估动脉参数。
该研究在法国、比利时和荷兰的学术医院和私人诊所进行。
患有轻度高胆固醇血症的绝经后妇女（n=538）。
无。
测量颈总动脉内膜中层厚度（CCA-IMT）、中心脉搏压和主动脉僵硬度（颈动脉-股动脉脉搏波速度），并进行中心质量控制。采用多元回归分析评估与动脉参数相关的可能协变量。
女性年龄为 58±6（平均值±标准差）岁，绝经年龄为 50±5 岁，绝经持续时间平均为 8±7 年。绝经年龄较低、绝经后时间较长和未使用 HT 与动脉参数恶化独立相关。经多元分析后发现，HT 与较低的 CCA-IMT 相关（-40μm[范围-64 至-1]），而较低的绝经年龄和绝经持续时间则分别与 CCA-IMT 增加相关（25μm/5 年和 27μm/5 年）。同样，HT 使用者的中心脉搏压和脉搏波速度值也较低（分别为-3.1mmHg[-5.1 至-0.9]和-0.31m/s[-0.63 至-0.02]），但随着绝经年龄和绝经持续时间的增加而恶化。
绝经年龄、绝经后时间和 HT 的使用与大动脉的增厚和僵硬独立相关。
NCT00163163。
