Neuronal Regeneration Laboratory, Centro de Investigacion Principe Felipe, Avd Autopista del Saler 16, 46012, Valencia, Spain.
Cell Mol Life Sci. 2012 Feb;69(4):519-34. doi: 10.1007/s00018-011-0813-4. Epub 2011 Oct 8.
Oxygen homeostasis determines the activity and expression of a multitude of cellular proteins and the interplay of pathways that affect crucial cellular processes for development, physiology, and pathophysiology. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment and drives cellular adaptation to such conditions. Selective gene expression under hypoxic conditions is the result of an exquisite regulation of HIF, from the pre-transcriptional stage of the HIF gene to the final transcriptional activity of HIF protein. We provide a dissected analysis of HIF modulation with special focus on hypoxic conditions and HIF pharmacological interventions that can guide the application of any future HIF-mediated therapy.
氧平衡决定了大量细胞蛋白的活性和表达，以及影响发育、生理和病理生理过程的关键细胞过程的途径相互作用。缺氧诱导因子 (HIF) 是转录因子，可响应细胞环境中可用氧气的变化，并促使细胞适应这些条件。在缺氧条件下的选择性基因表达是 HIF 精细调节的结果，从 HIF 基因的转录前阶段到 HIF 蛋白的最终转录活性。我们对 HIF 调节进行了剖析分析，特别关注缺氧条件和 HIF 药理学干预，这些可以指导任何未来基于 HIF 的治疗方法的应用。
