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血清网膜素-1 水平与代谢综合征患者冠状动脉疾病的存在和严重程度呈负相关。

Serum omentin-1 levels are inversely associated with the presence and severity of coronary artery disease in patients with metabolic syndrome.

机构信息

Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shanxi, P. R. China.

出版信息

Biomarkers. 2011 Dec;16(8):657-62. doi: 10.3109/1354750X.2011.622789. Epub 2011 Oct 11.

DOI:10.3109/1354750X.2011.622789
PMID:21988056
Abstract

CONTEXT

Omentin-1, an adipokine secreted from visceral adipose tissue, has been reported to be associated with coronary artery disease (CAD) and metabolic disorders.

OBJECTIVE

To clarify the relationship between serum omentin-1 levels and the presence and severity of CAD in patients with metabolic syndrome (MetS).

METHODS

We measured serum omentin-1 levels in 175 consecutive patients with MetS and in 46 controls.

RESULTS

Serum omentin-1 levels are inversely associated with the presence and angiographic severity of CAD in MetS patients.

CONCLUSIONS

Serum omentin-1 might be a potential biomarker to predict the development and progression of CAD in MetS patients.

摘要

背景

网膜素-1 是一种由内脏脂肪组织分泌的脂肪因子,已有研究报道其与冠状动脉疾病(CAD)和代谢紊乱相关。

目的

明确血清网膜素-1 水平与代谢综合征(MetS)患者 CAD 的发生和严重程度之间的关系。

方法

我们测量了 175 例连续 MetS 患者和 46 例对照者的血清网膜素-1 水平。

结果

血清网膜素-1 水平与 MetS 患者 CAD 的发生和血管造影严重程度呈负相关。

结论

血清网膜素-1 可能是预测 MetS 患者 CAD 发生和进展的潜在生物标志物。

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