设计生物杂交材料的生物相容性。

Designing the biocompatibility of biohybrids.

机构信息

Laboratory for Biomechanics and Biomaterials, Orthopaedic Clinic, Hannover Medical School, Anna-von-Borries-Straβe 1-7, 30625, Hannover, Germany,

出版信息

Adv Biochem Eng Biotechnol. 2012;126:285-96. doi: 10.1007/10_2011_114.

DOI:10.1007/10_2011_114

PMID:21989489

Abstract

Biohybrid has been used as a fashionable term in scientific publications during the past years to describe a functional unit consisting of a bioactive and a structural component. The bioactive part of the biohybrid could consist of cells or bioactive molecules, while the structural part is of biological or non-biological origin. Biohybrids are currently used as implants and transplants in regenerative medicine or in vitro applications such as assays, biosensors or bioreactors. However, a clear definition of a biohybrid has not been given yet. This chapter reviews the current applications of biohybrids and identifies the challenges of biohybrids in in vivo applications. A classification of biohybrids according to their functional use and application is provided.

摘要

在过去的几年中，“生物杂交体”在科学出版物中被用作一个时髦的术语，用来描述由生物活性成分和结构成分组成的功能单元。生物杂交体的生物活性部分可以由细胞或生物活性分子组成，而结构部分则具有生物或非生物来源。生物杂交体目前被用于再生医学中的植入物和移植，或在体外应用，如检测、生物传感器或生物反应器。然而，目前还没有给出生物杂交体的明确定义。本章回顾了生物杂交体的当前应用，并确定了生物杂交体在体内应用中所面临的挑战。根据其功能用途和应用对生物杂交体进行了分类。