Al-Jawad F H, Sahib A S, Al-Kaisy A A
Department of Pharmacology and Therapeutics, Al-Nahrain College of Medicine, Baghdad, Iraq.
Ann Burns Fire Disasters. 2008 Dec 31;21(4):186-91.
Burns are a major health problem worldwide, with high mortality and morbidity in addition to causing changes in the quality of life of burn patients. Utilizing antioxidant therapeutic strategies depending on new mechanisms involved in the pathogenesis of burns-related "oxidative stress" may be considered a promising step in burns management. This study involved 180 burn patients of varying age and either sex and with varying burns percentages. The patients were subdivided into six groups (A, B, C, D, E, and F); each group thus included 30 patients. Patients in groups B, C, D, E, and F were treated with antioxidants (vitamin E with vitamin C, zinc sulphate, allopurinol, melatonin, and N-acetylcysteine respectively) while group A was treated according to hospital policy, without any antioxidant; also, healthy subjects (group G) were involved in the study as a control group for comparison.In each group we examined serum malondialdehyde and serum glutathione levels, serum zinc and copper levels, liver function, renal function, mortality rate, and healing time, using standard methods. It was found that the administration of antioxidants to burn patients produced significant improvement in the parameters studied compared with group A (no antioxidant given). This study clearly shows the importance of the therapeutic targeting of oxidative stress in the treatment of burns. It is important to consider antioxidant a most effective weapon that must be added to the arsenal available in the combating of burn complications.
烧伤是全球范围内的一个主要健康问题，除了会改变烧伤患者的生活质量外，还具有高死亡率和发病率。根据烧伤相关“氧化应激”发病机制中涉及的新机制采用抗氧化治疗策略，可能被认为是烧伤治疗中有前景的一步。本研究纳入了180名不同年龄、性别及烧伤百分比的烧伤患者。患者被分为六组（A、B、C、D、E和F）；每组各有30名患者。B、C、D、E和F组的患者分别接受抗氧化剂治疗（维生素E与维生素C、硫酸锌、别嘌呤醇、褪黑素和N - 乙酰半胱氨酸），而A组按照医院常规治疗，未使用任何抗氧化剂；此外，健康受试者（G组）作为对照组参与研究以作比较。我们使用标准方法检测了每组患者的血清丙二醛和血清谷胱甘肽水平、血清锌和铜水平、肝功能、肾功能、死亡率及愈合时间。结果发现，与A组（未给予抗氧化剂）相比，给予烧伤患者抗氧化剂后，所研究的参数有显著改善。本研究清楚地表明了针对氧化应激进行治疗在烧伤治疗中的重要性。将抗氧化剂视为对抗烧伤并发症可用手段中必须添加的最有效武器是很重要的。
