Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, US National Institutes of Health, Frederick, Maryland, USA.
Nat Immunol. 2012 Oct;13(10):932-8. doi: 10.1038/ni.2422. Epub 2012 Sep 18.
Resistance mechanisms of the innate and adaptive immune responses prevent the colonization of foreign organisms in unwanted anatomical sites and participate in tissue repair and restoration of homeostasis after damage induced either by the invasion of pathogenic microbes or by the organism's response to them. The intensity of the response is controlled and limited by positive and negative feedback circuits that aim at preventing collateral tissue damage. In this Review we will discuss the protective and pathogenic effects of host-commensal microbiota mutualism on the immune response and illustrate some examples of collateral tissue and systemic damage caused by immunity to pathogens.
先天免疫和适应性免疫反应的抵抗机制阻止了外来生物体在不需要的解剖部位定植，并参与了组织修复和内稳态的恢复，这是由病原微生物的入侵或机体对其的反应所导致的损伤引起的。反应的强度受到正反馈和负反馈回路的控制和限制，这些回路旨在防止继发组织损伤。在这篇综述中，我们将讨论宿主共生菌群共栖对免疫反应的保护和致病作用，并举例说明针对病原体的免疫反应引起的继发组织和全身损伤。
