Department of Radiation Oncology, Arthur G James Comprehensive Cancer Center & Richard L Solove Research Institute, The Ohio State University Medical Center, Columbus, 43210, USA.
Future Oncol. 2011 Oct;7(10):1169-83. doi: 10.2217/fon.11.102.
Gliomas account for the vast majority of malignant adult brain tumors. Even though tremendous effort has been made to optimize treatment of patients with high-grade glioma, the prognosis remains poor, especially for patients with glioblastoma. The dismal prognosis conferred by these tumors is in part caused by the tendency to diffusely infiltrate into neighboring brain tissue, but also by the inherent resistance of these tumors to both chemotherapy and radiation. This article reviews the recent advancements in multimodality treatment of patients with gliomas, both in the primary and recurrent setting, with an emphasis on the emerging targeted therapies. Moreover, the external beam radiotherapy options, including intensity modulated radiotherapy and particle (proton and carbon ion) radiotherapy are reviewed.
神经胶质瘤占成人脑肿瘤的绝大多数。尽管为优化高级别神经胶质瘤患者的治疗做出了巨大努力，但预后仍然不佳，尤其是胶质母细胞瘤患者。这些肿瘤带来的不良预后部分是由于它们向邻近脑组织弥漫性浸润的倾向，也部分是由于这些肿瘤对化疗和放疗的固有耐药性。本文综述了在原发性和复发性脑胶质瘤患者的多模态治疗方面的最新进展，重点介绍了新兴的靶向治疗。此外，还回顾了外照射放疗的选择，包括调强放疗和粒子（质子和碳离子）放疗。
