Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT 06150, USA.
J Clin Gastroenterol. 2011 Nov;45 Suppl:S168-71. doi: 10.1097/MCG.0b013e318230928b.
This study describes the consensus opinion of the participants of the third Yale Workshop on probiotic use. There were 10 experts participating. The recommendations update those of the first 2 meetings that were published in 2005 and 2008. The workshop presentations and papers in this supplement relate to the involvement of normal microbiota involved in intestinal microecology, how the microbes interact with the intestine to affect our immunologic responses, the stability and natural history of probiotic organisms, and the role of the intestinal microbatome with regard to affecting cardiac risk factors and obesity. Recommendations for the use of probiotics in necrotizing enterocolitis, childhood diarrhea, inflammatory bowel disease, irritable bowel syndrome, and Clostridium difficile diarrhea are reviewed. As in previous publications, the recommendations are given as A, B, or C ratings. The recent positive experiences with bacteriotherapy (fecal microbiome transplant) are also discussed in detail and a positive recommendation is made for use in severe resistant C. difficile diarrhea.
本研究描述了第三届耶鲁益生菌使用研讨会参与者的共识意见。共有 10 名专家参加。这些建议更新了 2005 年和 2008 年发表的前两次会议的建议。本增刊中的研讨会报告和论文涉及参与肠道微生态学的正常微生物群、微生物如何与肠道相互作用影响我们的免疫反应、益生菌的稳定性和自然史，以及肠道微生物组对影响心脏危险因素和肥胖的作用。对益生菌在坏死性小肠结肠炎、儿童腹泻、炎症性肠病、肠易激综合征和艰难梭菌腹泻中的应用的建议进行了回顾。与以前的出版物一样，建议分为 A、B 或 C 级。最近在细菌治疗（粪便微生物群移植）方面的积极经验也进行了详细讨论，并对严重耐药艰难梭菌腹泻的使用提出了积极建议。
