Department of Virology, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, "Pedro Kouri" Tropical Medicine Institute of Havana, Cuba; E-Mail:
Viruses. 2010 Dec;2(12):2649-62. doi: 10.3390/v2122649. Epub 2010 Dec 8.
Antibody-dependent enhancement (ADE) has been proposed as a mechanism to explain dengue hemorrhagic fever (DHF) in the course of a secondary dengue infection. Very recently, Dejnirattisai et al., 2010 [1], published an important article supporting the involvement of anti-prM antibodies in the ADE phenomenon. The complexity of ADE in the context of a secondary dengue infection is discussed here.
抗体依赖的增强作用（ADE）被认为是解释二次登革热感染过程中登革出血热（DHF）的一种机制。最近，Dejnirattisai 等人，2010 [1]，发表了一篇重要文章，支持抗-prM 抗体在 ADE 现象中的作用。本文讨论了二次登革热感染中 ADE 的复杂性。
