艾滋病毒毒力的病毒遗传因素的有力证据。
A strong case for viral genetic factors in HIV virulence.
机构信息
Institute of Biology, Eötvös Loránd University, Pázmány P. s. 1/C, 1117 Budapest, Hungary.
Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London W2 1PG, UK.
出版信息
Viruses. 2011 Mar;3(3):204-216. doi: 10.3390/v3030204. Epub 2011 Mar 8.
Abstract
HIV infections show great variation in the rate of progression to disease, and the role of viral genetic factors in this variation had remained poorly characterized until recently. Now a series of four studies [1-4] published within a year has filled this important gap and has demonstrated a robust effect of the viral genotype on HIV virulence.
摘要
HIV 感染在向疾病发展的速度上存在很大差异，而病毒遗传因素在这种差异中的作用直到最近才得到充分描述。现在，一年内发表的一系列四项研究[1-4]填补了这一重要空白，并证明了病毒基因型对 HIV 毒力具有强大的影响。
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