艾滋病毒毒力的病毒遗传因素的有力证据。
A strong case for viral genetic factors in HIV virulence.
机构信息
Institute of Biology, Eötvös Loránd University, Pázmány P. s. 1/C, 1117 Budapest, Hungary.
Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London W2 1PG, UK.
出版信息
Viruses. 2011 Mar;3(3):204-216. doi: 10.3390/v3030204. Epub 2011 Mar 8.
Abstract
HIV infections show great variation in the rate of progression to disease, and the role of viral genetic factors in this variation had remained poorly characterized until recently. Now a series of four studies [1-4] published within a year has filled this important gap and has demonstrated a robust effect of the viral genotype on HIV virulence.
摘要
HIV 感染在向疾病发展的速度上存在很大差异，而病毒遗传因素在这种差异中的作用直到最近才得到充分描述。现在，一年内发表的一系列四项研究[1-4]填补了这一重要空白，并证明了病毒基因型对 HIV 毒力具有强大的影响。
相似文献
1
A strong case for viral genetic factors in HIV virulence.艾滋病毒毒力的病毒遗传因素的有力证据。
Viruses. 2011 Mar;3(3):204-216. doi: 10.3390/v3030204. Epub 2011 Mar 8.
2
Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe.在欧洲，病毒基因变异占HIV-1设定点病毒载量变异性的三分之一。
PLoS Biol. 2017 Jun 12;15(6):e2001855. doi: 10.1371/journal.pbio.2001855. eCollection 2017 Jun.
3
An HIV epidemic model based on viral load dynamics: value in assessing empirical trends in HIV virulence and community viral load.基于病毒载量动力学的 HIV 流行模型：评估 HIV 毒力和社区病毒载量的经验趋势的价值。
PLoS Comput Biol. 2014 Jun 19;10(6):e1003673. doi: 10.1371/journal.pcbi.1003673. eCollection 2014 Jun.
4
Virulence and pathogenesis of HIV-1 infection: an evolutionary perspective.HIV-1 感染的毒力和发病机制：一种进化角度的研究。
Science. 2014 Mar 21;343(6177):1243727. doi: 10.1126/science.1243727.
5
Virus-induced target cell activation reconciles set-point viral load heritability and within-host evolution.病毒诱导的靶细胞激活调和了设定点病毒载量的遗传力和体内进化。
Epidemics. 2013 Dec;5(4):174-80. doi: 10.1016/j.epidem.2013.09.002. Epub 2013 Sep 23.
6
Is HIV-1 evolving to a less virulent form in humans?HIV-1 在人类中是否正在演变成毒性较低的形式？
Nat Rev Microbiol. 2007 Feb;5(2):141-51. doi: 10.1038/nrmicro1594. Epub 2007 Jan 4.
7
A highly virulent variant of HIV-1 circulating in the Netherlands.在荷兰流行的一种高毒力 HIV-1 变异体。
Science. 2022 Feb 4;375(6580):540-545. doi: 10.1126/science.abk1688. Epub 2022 Feb 3.
8
HIV-1 transmitting couples have similar viral load set-points in Rakai, Uganda.在乌干达的拉凯，HIV-1 传播的夫妇具有相似的病毒载量设定点。
PLoS Pathog. 2010 May 6;6(5):e1000876. doi: 10.1371/journal.ppat.1000876.
9
Parent-offspring regression to estimate the heritability of an HIV-1 trait in a realistic setup.在实际情况下，通过亲子回归来估计HIV-1性状的遗传力。
Retrovirology. 2017 May 23;14(1):33. doi: 10.1186/s12977-017-0356-3.
10
Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T-Cell Decline, and Per-Parasite Pathogenicity.解析 HIV 毒力：准种病毒载量、CD4+T 细胞下降和每寄生虫致病性的遗传性。
Mol Biol Evol. 2018 Jan 1;35(1):27-37. doi: 10.1093/molbev/msx246.
引用本文的文献
1
Phylogenetics and molecular evolution to understand and curb the HIV pandemic.利用系统发育学和分子进化来理解和遏制艾滋病大流行。
Nat Rev Microbiol. 2025 Jun 30. doi: 10.1038/s41579-025-01202-w.
2
Evolution of HIV virulence in response to disease-modifying vaccines: A modeling study.HIV 病毒毒力对疾病修正性疫苗的响应演变：建模研究。
Vaccine. 2023 Oct 13;41(43):6461-6469. doi: 10.1016/j.vaccine.2023.08.071. Epub 2023 Sep 14.
3
Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors.严重 COVID-19 的风险因素：宿主、病毒和环境因素的综述。
Viruses. 2023 Jan 7;15(1):175. doi: 10.3390/v15010175.
4
Herpes Simplex Virus-2 Variation Contributes to Neurovirulence During Neonatal Infection.单纯疱疹病毒-2 变异有助于新生儿感染期间的神经毒力。
J Infect Dis. 2022 Nov 1;226(9):1499-1509. doi: 10.1093/infdis/jiac151.
5
Human Adenovirus Type 4 Comprises Two Major Phylogroups with Distinct Replicative Fitness and Virulence Phenotypes.人腺病毒 4 型包含两个主要的进化枝，具有不同的复制适应性和毒力表型。
J Virol. 2022 Mar 9;96(5):e0109021. doi: 10.1128/JVI.01090-21. Epub 2021 Jul 7.
6
Genotypic and Phenotypic Diversity of Herpes Simplex Virus 2 within the Infected Neonatal Population.单纯疱疹病毒 2 感染新生儿群体中的基因型和表型多样性。
mSphere. 2019 Feb 27;4(1):e00590-18. doi: 10.1128/mSphere.00590-18.
7
Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T-Cell Decline, and Per-Parasite Pathogenicity.解析 HIV 毒力：准种病毒载量、CD4+T 细胞下降和每寄生虫致病性的遗传性。
Mol Biol Evol. 2018 Jan 1;35(1):27-37. doi: 10.1093/molbev/msx246.
8
Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control.评估人类和病毒基因变异对HIV控制的各自贡献。
PLoS Comput Biol. 2017 Feb 9;13(2):e1005339. doi: 10.1371/journal.pcbi.1005339. eCollection 2017 Feb.
9
Prognostic Value of HIV-1 RNA on CD4 Trajectories and Disease Progression Among Antiretroviral-Naive HIV-Infected Adults in Botswana: A Joint Modeling Analysis.博茨瓦纳未接受抗逆转录病毒治疗的HIV感染成人中，HIV-1 RNA对CD4轨迹和疾病进展的预后价值：一项联合建模分析
AIDS Res Hum Retroviruses. 2016 Jun;32(6):573-8. doi: 10.1089/AID.2015.0348. Epub 2016 Mar 3.
10
The impact of antiretroviral therapy on population-level virulence evolution of HIV-1.抗逆转录病毒疗法对HIV-1群体水平毒力进化的影响。
J R Soc Interface. 2015 Dec 6;12(113):20150888. doi: 10.1098/rsif.2015.0888.
本文引用的文献
1
Is the virulence of HIV changing? A meta-analysis of trends in prognostic markers of HIV disease progression and transmission.HIV 的毒力是否在发生变化？一项关于 HIV 疾病进展和传播的预后标志物趋势的荟萃分析。
AIDS. 2012 Jan 14;26(2):193-205. doi: 10.1097/QAD.0b013e32834db418.
2
Phylogenetic approach reveals that virus genotype largely determines HIV set-point viral load.系统进化方法揭示病毒基因型在很大程度上决定了 HIV 病毒载量的基准值。
PLoS Pathog. 2010 Sep 30;6(9):e1001123. doi: 10.1371/journal.ppat.1001123.
3
Interpretation of correlations in setpoint viral load in transmitting couples.对传播性伴侣中设定点病毒载量相关性的解读。
AIDS. 2010 Oct 23;24(16):2596-7. doi: 10.1097/QAD.0b013e32833e7a64.
4
CXCR4-using viruses in plasma and peripheral blood mononuclear cells during primary HIV-1 infection and impact on disease progression.在原发性 HIV-1 感染期间，血浆和外周血单个核细胞中使用 CXCR4 的病毒及其对疾病进展的影响。
AIDS. 2010 Sep 24;24(15):2305-12. doi: 10.1097/QAD.0b013e32833e50bb.
5
The effect of transmitted HIV-1 drug resistance on pre-therapy viral load.传播的 HIV-1 耐药性对治疗前病毒载量的影响。
AIDS. 2010 Jul 31;24(12):1917-22. doi: 10.1097/QAD.0b013e32833c1d93.
6
HIV RNA levels in transmission sources only weakly predict plasma viral load in recipients.传播源中的HIV RNA水平对接受者血浆病毒载量的预测能力较弱。
AIDS. 2010 Jun 19;24(10):1607-8. doi: 10.1097/QAD.0b013e32833b318f.
7
High Multiplicity Infection by HIV-1 in Men Who Have Sex with Men.男男性行为者中 HIV-1 的高多重感染。
PLoS Pathog. 2010 May 13;6(5):e1000890. doi: 10.1371/journal.ppat.1000890.
8
HIV-1 transmitting couples have similar viral load set-points in Rakai, Uganda.在乌干达的拉凯，HIV-1 传播的夫妇具有相似的病毒载量设定点。
PLoS Pathog. 2010 May 6;6(5):e1000876. doi: 10.1371/journal.ppat.1000876.
9
Host determinants of HIV-1 control in African Americans.非洲裔美国人中 HIV-1 控制的宿主决定因素。
J Infect Dis. 2010 Apr 15;201(8):1141-9. doi: 10.1086/651382.
10
HIV RNA level in early infection is predicted by viral load in the transmission source.HIV RNA 水平在早期感染中可由传播源中的病毒载量预测。
AIDS. 2010 Apr 24;24(7):941-5. doi: 10.1097/QAD.0b013e328337b12e.
Zotero 插件