SWI2/SNF2 ATPase 的调控和作用的结构见解。
Structural insights into regulation and action of SWI2/SNF2 ATPases.
机构信息
TC Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218-2685, USA.
出版信息
Curr Opin Struct Biol. 2011 Dec;21(6):719-27. doi: 10.1016/j.sbi.2011.09.003. Epub 2011 Oct 11.
Abstract
This review focuses on recent structural insights into regulation and nucleic acid binding of Superfamily 2 (SF2)-type helicases as they relate to chromatin remodelers. We review structural features of the Chd1 chromatin remodeler regarding regulation of the ATPase motor, and discuss related strategies observed for other SF2 ATPases. Since no SWI2/SNF2 ATPases have yet been captured bound to DNA in a state competent for ATP hydrolysis, we turn to structural examples from the DEAD-box RNA helicase family, and suggest that SWI2/SNF2-specific inserts may be poised to alter canonical duplex DNA structure.
摘要
这篇综述重点关注了 Superfamily 2（SF2）- 型解旋酶在与染色质重塑剂相关的调节和核酸结合方面的最新结构见解。我们综述了 Chd1 染色质重塑剂在调节 ATP 酶马达方面的结构特征，并讨论了其他 SF2 ATP 酶中观察到的相关策略。由于迄今为止尚未捕获到处于能够进行 ATP 水解的状态的 SWI2/SNF2 ATP 酶结合到 DNA 上，因此我们转向 DEAD-box RNA 解旋酶家族的结构实例，并提出 SWI2/SNF2 特异性插入可能准备好改变典型的双链 DNA 结构。
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