海洋蓝细菌来源的拟大麻素脂质。
Cannabinomimetic lipid from a marine cyanobacterium.
机构信息
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography , and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.
出版信息
J Nat Prod. 2011 Oct 28;74(10):2313-7. doi: 10.1021/np200610t. Epub 2011 Oct 14.
Abstract
NMR-guided fractionation of two independent collections of the marine cyanobacteria Lyngbya majuscula obtained from Papua New Guinea and Oscillatoria sp. collected in Panama led to the isolation of the new lipids serinolamide A (3) and propenediester (4). Their structures were determined by NMR and MS data analysis. Serinolamide A (3) exhibited a moderate agonist effect and selectivity for the CB1 cannabinoid receptor (Ki=1.3 μM, >5-fold) and represents the newest addition to the known cannabinomimetic natural products of marine origin.
摘要
从巴布亚新几内亚获得的海洋蓝藻 Lyngbya majuscula 和在巴拿马收集的 Oscillatoria sp. 的两个独立样本的 NMR 引导分离，导致了新脂质丝氨醇酰胺 A（3）和丙二烯酯（4）的分离。它们的结构通过 NMR 和 MS 数据分析确定。丝氨醇酰胺 A（3）对 CB1 大麻素受体表现出中等激动作用和选择性（Ki=1.3 μM，>5 倍），是海洋来源的已知大麻素模拟天然产物的最新成员。
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