Department of Chemistry, State University of New York at Binghamton, Binghamton, New York 13902, United States.
Anal Chem. 2011 Nov 15;83(22):8688-95. doi: 10.1021/ac202164p. Epub 2011 Oct 14.
The ability for silver nanoparticles to function as an antibacterial agent while being separable from the target fluids is important for bacterial inactivation in biological fluids. This report describes the analysis of the antimicrobial activities of silver-coated magnetic nanoparticles synthesized by wet chemical methods. The bacterial inactivation of several types of bacteria was analyzed, including Gram-positive bacteria ( Staphylococcus aureus and Bacillus cereus ) and Gram-negative bacteria ( Pseudomonas aeruginosa , Enterobacter cloacae , and Escherichia coli ). The results have demonstrated the viability of the silver-coated magnetic nanoparticles for achieving effective bacterial inactivation efficiency comparable to and better than that of silver nanoparticles conventionally used. The bacteria inactivation efficiency of our silver-coated MnZn ferrite (MZF@Ag) nanoparticles was also determined for blood platelets samples, demonstrating the potential of utilization in inactivating bacterial growth in platelets prior to transfusion to ensure blood product safety, which also has important implications for enabling the capability of effective separation, delivery, and targeting of the antibacterial agents.
银纳米粒子能够在与目标流体分离的同时发挥抗菌作用，这对于在生物流体中灭活细菌非常重要。本报告描述了通过湿化学方法合成的银包覆磁性纳米粒子的抗菌活性分析。分析了几种类型细菌的细菌失活动力学，包括革兰氏阳性菌（金黄色葡萄球菌和蜡状芽孢杆菌）和革兰氏阴性菌（铜绿假单胞菌、阴沟肠杆菌和大肠杆菌）。结果表明，银包覆磁性纳米粒子具有实现有效细菌灭活效率的可行性，可与传统使用的银纳米粒子相媲美，甚至更好。我们的银包覆 MnZn 铁氧体（MZF@Ag）纳米粒子对血小板样本的细菌灭活效率也进行了测定，表明其在输血前灭活血小板中细菌生长的潜力，以确保血液制品的安全性，这也为有效分离、输送和靶向抗菌剂的能力提供了重要依据。
