Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box 14155-6117, Tehran, Iran.
BMC Womens Health. 2022 Sep 12;22(1):374. doi: 10.1186/s12905-022-01957-x.
Previous studies have shown the association of a number of dietary quality scores with metabolically phenotypes of obesity. Recently, the Lifelines Diet Score (LLDS), which is a fully food-based score based on the 2015 Dutch dietary guidelines and underlying international literature, has been proposed as a tool for assessing the quality of the diet. Therefore, this study was performed to investigate the association between LLDS and metabolically healthy/unhealthy overweight and obesity (MHO/MUHO) phenotypes.
This study was performed on 217 women, aged 18-48 years old. For each participant anthropometric values, biochemical test and body composition were evaluated by standard protocols and methods. The LLDS was determined based on 12 components using a valid and reliable food frequency questionnaire (FFQ) containing 147 items. The metabolically healthy (MH) was evaluated using the Karelis criteria.
Among the total participants in this study, 31.3% of the subjects were MHO while 68.7% were MUHO. After adjustment for potential confounding variables (age, energy intake, and physical activity), participants in highest LLDS tertile had a lower odds of MUHO compared with those in the lowest tertile (OR: 1.18; 95% CI: 0.23, 5.83; P-trend = 0.03). Also, after further adjustment with BMI, provided only small changes in "OR" and did not attenuate the significance (OR: 1.28; 95% CI: 0.23, 6.91; P-trend = 0.02).
The present evidence indicates that individuals with higher adherence to the LLDS had lower odds of metabolically unhealthy (MUH).
先前的研究表明，许多饮食质量评分与肥胖的代谢表型有关。最近，Lifelines 饮食评分（LLDS）作为一种基于 2015 年荷兰饮食指南和基础国际文献的完全基于食物的评分方法，已被提出作为评估饮食质量的工具。因此，本研究旨在探讨 LLDS 与代谢健康/不健康超重和肥胖（MHO/MUHO）表型之间的关系。
本研究纳入了 217 名年龄在 18-48 岁之间的女性。根据标准方案和方法，对每位参与者的人体测量值、生化测试和身体成分进行评估。根据包含 147 个项目的有效和可靠的食物频率问卷（FFQ），通过 12 个成分确定 LLDS。采用 Karelis 标准评估代谢健康（MH）。
在本研究的所有参与者中，31.3%的受试者为 MHO，而 68.7%的受试者为 MUHO。在调整了潜在的混杂变量（年龄、能量摄入和体力活动）后，与最低 tertile 相比，最高 tertile 的参与者 MUHO 的几率较低（OR：1.18；95%CI：0.23，5.83；P-trend=0.03）。此外，在进一步调整 BMI 后，“OR”的变化很小，且不减弱其显著性（OR：1.28；95%CI：0.23，6.91；P-trend=0.02）。
本研究结果表明，较高的 LLDS 依从性与代谢不健康（MUH）的几率较低有关。
