利用光声相关光谱法测量毛细血管中的活体血流速度。
In vivo flow speed measurement of capillaries by photoacoustic correlation spectroscopy.
机构信息
Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan 48109, USA.
出版信息
Opt Lett. 2011 Oct 15;36(20):4017-9. doi: 10.1364/OL.36.004017.
Abstract
We recently proposed photoacoustic correlation spectroscopy (PACS) and demonstrated a proof-of-concept experiment. Here we use the technique for in vivo flow speed measurement in capillaries in a chick embryo model. The photoacoustic microscopy system is used to render high spatial resolution and high sensitivity, enabling sufficient signals from single red blood cells. The probe beam size is calibrated by a blood-mimicking phantom. The results indicate the feasibility of using PACS to study flow speeds in capillaries.
摘要
我们最近提出了光声相关光谱（PACS）技术并进行了原理验证实验。在此，我们将该技术应用于鸡胚模型中小血管内的血流速度测量。该光声显微镜系统具有高空间分辨率和高灵敏度，可以从单个红细胞中获得足够的信号。通过血液模拟体对探测光束尺寸进行标定。结果表明，PACS 技术可用于研究毛细血管中的血流速度。
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