Goldstein R A, Rohatgi P K, Bergofsky E H, Block E R, Daniele R P, Dantzker D R, Davis G S, Hunninghake G W, King T E, Metzger W J
Am Rev Respir Dis. 1990 Aug;142(2):481-6. doi: 10.1164/ajrccm/142.2.481.
BAL remains a powerful investigative tool. In a short span of 20 yr, it has helped tremendously in understanding some of the aspects of the pathogenesis of diseases involving the lower respiratory tract. To realize its full potential in the diagnosis and management of diseases involving the lower respiratory tract, there is a great need for standardization of the technical aspects of BAL as well as processing and analysis of the BAL cellular- and fluid-phase components. Despite these hurdles, BAL has been found to be diagnostic in several infectious and noninfectious diseases involving the lower respiratory tract, and it provides valuable information that may be helpful in characterizing the prognosis and response to therapy in certain interstitial diseases of the lung. It is expected that with future research, in particular long-term prospective epidemiologic and clinical studies in pneumoconioses and in other interstitial lung disease, BAL will prove more valuable in the diagnosis and management of such disease.
支气管肺泡灌洗术（BAL）仍然是一种强大的研究工具。在短短20年的时间里，它在理解涉及下呼吸道疾病发病机制的某些方面发挥了巨大作用。为了充分发挥其在涉及下呼吸道疾病诊断和管理中的潜力，迫切需要对BAL的技术方面以及BAL细胞和液相成分的处理与分析进行标准化。尽管存在这些障碍，但已发现BAL对多种涉及下呼吸道的感染性和非感染性疾病具有诊断价值，并且它提供的有价值信息可能有助于确定某些间质性肺病的预后和对治疗的反应。预计随着未来的研究，特别是在尘肺病和其他间质性肺病方面的长期前瞻性流行病学和临床研究，BAL在这类疾病的诊断和管理中将被证明更有价值。
