Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Jeonnam 58554, Korea.
Department of Dental Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 Plus, Chonbuk National University, Jeonju 56443, Korea.
Molecules. 2019 Feb 14;24(4):680. doi: 10.3390/molecules24040680.
Seib ex TANAKA possesses various biological effects. It has been used in oriental remedies for blood circulation and the common cold. Recently, biological effects of peel have been reported. However, optimization of the biological properties of peel preparations has yet to be reported on. We developed a high-performance liquid chromatography (HPLC) method for quantification of the active constituents in peel. Hot water and ethanolic extracts of peel were prepared and their chemical profiles and biological activities were evaluated. The 80% ethanolic extract demonstrated the greatest antioxidant activity and phenolic content, while the 100% ethanolic extract had the greatest xanthine oxidase inhibitory activity. Elastase inhibition activity was superior in aqueous and 20% ethanolic extracts. The contents of two flavonoids were highest in the 100% ethanolic extract. We postulated that the antioxidant and anti-aging effects of peel extract could be attributed to phenolics such as flavonoids. Our results suggest that the flavonoid-rich extract of may be utilized for the treatment and prevention of metabolic disease and hyperuricemia while the water-soluble extract of could be used as a source for its anti-aging properties.
山竹壳具有多种生物学效应。它在东方的血液循环和感冒的药物中被使用。最近，山竹壳的生物学效应已经被报道。然而，山竹壳制剂的生物学特性的优化尚未被报道。我们开发了一种高效液相色谱 (HPLC) 方法来定量山竹壳中的活性成分。制备了山竹壳的热水和乙醇提取物，并评估了它们的化学特征和生物活性。80%乙醇提取物表现出最大的抗氧化活性和酚类含量，而 100%乙醇提取物具有最大的黄嘌呤氧化酶抑制活性。弹性蛋白酶抑制活性在水相和 20%乙醇提取物中较高。两种类黄酮的含量在 100%乙醇提取物中最高。我们推测，山竹壳提取物的抗氧化和抗衰老作用可能归因于类黄酮等酚类物质。我们的结果表明，富含类黄酮的山竹壳提取物可用于治疗和预防代谢疾病和高尿酸血症，而山竹壳的水溶性提取物可作为其抗衰老特性的来源。
