Department of Psychology, Michigan State University, East Lansing, MI 48824, USA.
Cogn Affect Behav Neurosci. 2012 Mar;12(1):193-206. doi: 10.3758/s13415-011-0066-6.
Disruption of the dorsal frontostriatal pathways in Parkinson's disease (PD) is associated with impairments in motivation, as well as in executive function. The goal of this study was to investigate whether these impairments are related and, if so, whether the disruption of frontostriatal pathways compromises the ability to process the motivational aspects of feedback in such tasks. In Experiment 1, informative feedback improved the performance of young, healthy participants in a task-switching paradigm. This task-switching paradigm was then used in Experiment 2 to test whether feedback would improve the performance of 17 PD patients and age-matched controls. The PD group benefitted from feedback to the same degree as control participants; however, depression scores on the Beck Depression Inventory were significantly related to feedback usage, especially when response selection demands were high. Regardless of feedback, PD patients were more impaired when response demands were high than in an equally difficult condition with low action demands. These results suggest that response selection is a core impairment of insufficient dopamine to the dorsal frontal striatal pathways.
帕金森病（PD）中背侧额纹状体通路的中断与动机以及执行功能的损伤有关。本研究的目的是探讨这些损伤是否相关，如果相关，那么额纹状体通路的中断是否会影响在这些任务中处理反馈的动机方面的能力。在实验 1 中，信息反馈改善了年轻健康参与者在任务转换范式中的表现。然后，在实验 2 中，我们使用这种任务转换范式来测试反馈是否会改善 17 名 PD 患者和年龄匹配的对照组的表现。PD 组受益于反馈的程度与对照组相同；然而，贝克抑郁量表的抑郁评分与反馈使用显著相关，尤其是在反应选择要求较高时。无论是否有反馈，当反应需求较高时，PD 患者的表现都比在同样困难但动作需求较低的情况下更差。这些结果表明，反应选择是背侧额纹状体通路多巴胺不足的核心损伤。
