Uihlein Lily C, Brandling-Bennett Heather A, Lio Peter A, Liang Marilyn G
Harvard Combined Dermatology Residency Training Program, Boston, Massachusetts, USA.
Pediatr Dermatol. 2012 Jan-Feb;29(1):38-44. doi: 10.1111/j.1525-1470.2011.01534.x. Epub 2011 Oct 20.
The objective of this study was to describe the clinical features of Sweet syndrome in children. Our study population consisted of seven children diagnosed with Sweet syndrome over a 22-year period. Age, sex, appearance and location of lesions, associated signs and symptoms, past medical history, pathology, and subsequent disease course were documented for each patient. Fever and typical lesions were reported in most of patients in our study. The majority of patients presented with less-typical findings, such as pustules, vesicles, bullae, oral ulcerations, atrophic scars, and evidence of pathergy. Of the seven children in our study, four were found to have a preceding nonspecific upper respiratory or gastrointestinal infection, and two were diagnosed with an underlying hematologic malignancy. Our results suggest that atypical lesions are relatively common in children with Sweet syndrome and that underlying malignancy is associated with a minority of cases of pediatric Sweet syndrome.
本研究的目的是描述儿童Sweet综合征的临床特征。我们的研究对象包括在22年期间被诊断为Sweet综合征的7名儿童。记录了每位患者的年龄、性别、皮损外观和部位、相关体征和症状、既往病史、病理情况及后续病程。在我们的研究中，大多数患者有发热和典型皮损。大多数患者表现为不太典型的表现，如脓疱、水疱、大疱、口腔溃疡、萎缩性瘢痕及同形反应证据。在我们研究的7名儿童中，4名在发病前有非特异性上呼吸道或胃肠道感染，2名被诊断有潜在血液系统恶性肿瘤。我们的结果表明，非典型皮损在儿童Sweet综合征中相对常见，且潜在恶性肿瘤与少数儿童Sweet综合征病例相关。
