Department of Clinical and Molecular Medicine, La Sapienza University, Rome, Italy.
Diabetes Care. 2012 Jan;35(1):39-41. doi: 10.2337/dc11-1450. Epub 2011 Oct 19.
To examine the effect of supervised exercise on traditional and nontraditional cardiovascular risk factors in sedentary, overweight/obese insulin-treated subjects with type 2 diabetes from the Italian Diabetes Exercise Study (IDES).
The study randomized 73 insulin-treated patients to twice weekly supervised aerobic and resistance training plus structured exercise counseling (EXE) or to counseling alone (CON) for 12 months. Clinical and laboratory parameters were assessed at baseline and at the end of the study.
The volume of physical activity was significantly higher in the EXE versus the CON group. Values for hemoglobin A(1c), BMI, waist circumference, high-sensitivity C-reactive protein, blood pressure, LDL cholesterol, and the coronary heart disease risk score were significantly reduced only in the EXE group. No major adverse events were observed.
In insulin-treated subjects with type 2 diabetes, supervised exercise is safe and effective in improving glycemic control and markers of adiposity and inflammation, thus counterbalancing the adverse effects of insulin on these parameters.
观察监督运动对意大利糖尿病运动研究（IDES）中久坐、超重/肥胖的胰岛素治疗 2 型糖尿病患者的传统和非传统心血管危险因素的影响。
该研究将 73 名接受胰岛素治疗的患者随机分为每周两次的监督有氧运动和抗阻训练加结构化运动咨询（EXE）组或仅接受咨询（CON）组，为期 12 个月。在基线和研究结束时评估临床和实验室参数。
EXE 组的体力活动量明显高于 CON 组。血红蛋白 A1c、BMI、腰围、高敏 C 反应蛋白、血压、LDL 胆固醇和冠心病风险评分仅在 EXE 组显著降低。未观察到重大不良事件。
在 2 型糖尿病接受胰岛素治疗的患者中，监督运动是安全有效的，可以改善血糖控制和肥胖和炎症标志物，从而抵消胰岛素对这些参数的不利影响。
