Buré A, Legrand P, Arlet G, Jarlier V, Paul G, Philippon A
Service de Bactériologie, Hôpital Claude Bernard, Paris, France.
Eur J Clin Microbiol Infect Dis. 1988 Dec;7(6):780-2. doi: 10.1007/BF01975048.
A strain of Klebsiella pneumoniae K25 resistant to newer beta-lactam drugs was isolated in clusters in five hospitals in the Paris area. The MICs of ceftazidime and aztreonam (greater than or equal to 128 mg/l) were higher than that of cefotaxime (16 mg/l) for the strain but, when measured in the presence of clavulanic acid, they were less than or equal to 1 mg/l. The donor strains and derivatives produced a beta-lactamase with a pI of 7.75-7.8 and hydrolysing activity against a wide spectrum of beta-lactams similar to that of SHV-2 and SHV-3, but with significant hydrolysis of ceftazidime. This new enzyme could be designated SHV-4.
在巴黎地区的五家医院中，呈簇状分离出了一株对新型β-内酰胺类药物耐药的肺炎克雷伯菌K25。对于该菌株，头孢他啶和氨曲南的最低抑菌浓度（大于或等于128mg/L）高于头孢噻肟（16mg/L），但在克拉维酸存在的情况下进行测定时，它们小于或等于1mg/L。供体菌株及其衍生物产生了一种pI为7.75 - 7.8的β-内酰胺酶，其对多种β-内酰胺类药物的水解活性与SHV-2和SHV-3相似，但对头孢他啶有显著水解作用。这种新酶可命名为SHV-4。
