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热休克蛋白:免疫与免疫病理学

Heat shock proteins: immunity and immunopathology.

作者信息

Lydyard P M, van Eden W

机构信息

Dept of Immunology, University College, Middlesex School of Medicine, London, UK.

出版信息

Immunol Today. 1990 Jul;11(7):228-9. doi: 10.1016/0167-5699(90)90091-m.

DOI:10.1016/0167-5699(90)90091-m
PMID:2201306
Abstract

Much interest has been generated in heat shock proteins (hsps) since they were implicated as dominant antigens of infectious microorganisms and suggested to have a role in the development of adjuvant arthritis (AA) in rats. Advances in the understanding of the role of hsps in immunity and immunopathology were recently discussed at a meeting held in Utrecht, as part of the European Community concerted action on immunopathogenesis and immunotherapy of chronic arthritis.

摘要

自从热休克蛋白(hsps)被认为是传染性微生物的主要抗原,并被认为在大鼠佐剂性关节炎(AA)的发展中起作用以来,人们对它产生了浓厚的兴趣。最近,在乌得勒支举行的一次会议上讨论了对热休克蛋白在免疫和免疫病理学中作用的理解进展,该会议是欧洲共同体关于慢性关节炎免疫发病机制和免疫治疗的协调行动的一部分。

相似文献

1
Heat shock proteins: immunity and immunopathology.热休克蛋白:免疫与免疫病理学
Immunol Today. 1990 Jul;11(7):228-9. doi: 10.1016/0167-5699(90)90091-m.
2
Heat-shock proteins as immunogenic bacterial antigens with the potential to induce and regulate autoimmune arthritis.热休克蛋白作为具有诱导和调节自身免疫性关节炎潜力的免疫原性细菌抗原。
Immunol Rev. 1991 Jun;121:5-28. doi: 10.1111/j.1600-065x.1991.tb00821.x.
3
[Stress proteins and autoimmune diseases].[应激蛋白与自身免疫性疾病]
Nihon Naika Gakkai Zasshi. 1997 Jun 10;86(6):1048-54. doi: 10.2169/naika.86.1048.
4
Antibodies to the mycobacterial 65-kd heat-shock protein are reactive with synovial tissue of adjuvant arthritic rats and patients with rheumatoid arthritis and osteoarthritis.针对分枝杆菌65-kd热休克蛋白的抗体与佐剂性关节炎大鼠以及类风湿性关节炎和骨关节炎患者的滑膜组织发生反应。
Am J Pathol. 1990 Nov;137(5):1013-7.
5
Heat-shock proteins: immunity and autoimmunity.热休克蛋白:免疫与自身免疫
Curr Opin Immunol. 1992 Aug;4(4):396-400. doi: 10.1016/s0952-7915(06)80029-4.
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Role of the bowel flora for development of immunity to hsp 65 and arthritis in three experimental models.肠道菌群在三种实验模型中对热休克蛋白65免疫及关节炎发展的作用
Scand J Immunol. 1994 Dec;40(6):648-52. doi: 10.1111/j.1365-3083.1994.tb03518.x.
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Autoimmunity to hsp65 and the immunologic paradigm.针对热休克蛋白65的自身免疫与免疫学范式。
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8
Resistance to adjuvant arthritis is due to protective antibodies against heat shock protein surface epitopes and the induction of IL-10 secretion.对佐剂性关节炎的抗性归因于针对热休克蛋白表面表位的保护性抗体以及白细胞介素-10分泌的诱导。
J Immunol. 2002 Jun 15;168(12):6463-9. doi: 10.4049/jimmunol.168.12.6463.
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Self heat-shock protein 65-mediated regulation of autoimmune arthritis.自身热休克蛋白 65 介导体液性自身免疫性关节炎的调节。
J Autoimmun. 2009 Nov-Dec;33(3-4):208-13. doi: 10.1016/j.jaut.2009.09.007. Epub 2009 Oct 2.
10
Regulation of autoimmune arthritis by self-heat-shock proteins.自身热休克蛋白对自身免疫性关节炎的调节作用。
Trends Immunol. 2008 Sep;29(9):412-8. doi: 10.1016/j.it.2008.06.003.

引用本文的文献

1
Heat shock proteins and kidney disease: perspectives of HSP therapy.热休克蛋白与肾脏疾病:热休克蛋白治疗的前景
Cell Stress Chaperones. 2017 May;22(3):319-343. doi: 10.1007/s12192-017-0790-0. Epub 2017 Apr 13.
2
Serological investigation of Chlamydia trachomatis heat shock protein 10.沙眼衣原体热休克蛋白10的血清学调查
Infect Immun. 1999 Oct;67(10):5243-6. doi: 10.1128/IAI.67.10.5243-5246.1999.
3
Identification of a 71-kilodalton surface-associated Hsp70 homologue in Coxiella burnetii.在伯纳特柯克斯体中鉴定出一种71千道尔顿的表面相关热休克蛋白70同源物。
Infect Immun. 1998 Dec;66(12):5882-8. doi: 10.1128/IAI.66.12.5882-5888.1998.
4
Use of monoclonal antibodies to facilitate identification, cloning, and purification of Chlamydia trachomatis hsp10.利用单克隆抗体促进沙眼衣原体热休克蛋白10的鉴定、克隆及纯化。
J Clin Microbiol. 1997 May;35(5):1209-15. doi: 10.1128/jcm.35.5.1209-1215.1997.
5
Induction of heat shock protein 60 expression in human monocytic cell lines infected with Mycobacterium leprae.麻风分枝杆菌感染的人单核细胞系中热休克蛋白60表达的诱导
Infect Immun. 1996 Oct;64(10):4356-8. doi: 10.1128/iai.64.10.4356-4358.1996.
6
Gamma interferon levels during Chlamydia trachomatis pneumonia in mice.小鼠沙眼衣原体肺炎期间的γ干扰素水平。
Infect Immun. 1993 Aug;61(8):3556-8. doi: 10.1128/iai.61.8.3556-3558.1993.
7
Lyme borreliosis: host responses to Borrelia burgdorferi.莱姆病:宿主对伯氏疏螺旋体的反应。
Microbiol Rev. 1991 Mar;55(1):21-34. doi: 10.1128/mr.55.1.21-34.1991.
8
A 66-kilodalton heat shock protein of Salmonella typhimurium is responsible for binding of the bacterium to intestinal mucus.鼠伤寒沙门氏菌的一种66千道尔顿热休克蛋白负责该细菌与肠道黏液的结合。
Infect Immun. 1992 Aug;60(8):3072-8. doi: 10.1128/iai.60.8.3072-3078.1992.
9
Prevention of adjuvant arthritis in rats by a nonapeptide from the 65-kD mycobacterial heat shock protein: specificity and mechanism.来自65-kD分枝杆菌热休克蛋白的九肽对大鼠佐剂性关节炎的预防作用:特异性及机制
Clin Exp Immunol. 1992 Jan;87(1):99-104. doi: 10.1111/j.1365-2249.1992.tb06420.x.