原理：一种通过网络传播将基因与疾病关联起来的工具。
PRINCIPLE: a tool for associating genes with diseases via network propagation.
机构信息
The Balavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel.
出版信息
Bioinformatics. 2011 Dec 1;27(23):3325-6. doi: 10.1093/bioinformatics/btr584. Epub 2011 Oct 20.
SUMMARY
PRINCIPLE is a Java application implemented as a Cytoscape plug-in, based on a previously published algorithm, PRINCE. Given a query disease, it prioritizes disease-related genes based on their closeness in a protein-protein interaction network to genes causing phenotypically similar disorders to the query disease.
AVAILABILITY
Implemented in Java, PRINCIPLE runs over Cytoscape 2.7 or newer versions. Binaries, default input files and documentation are freely available at http://www.cs.tau.ac.il/~bnet/software/PrincePlugin/.
CONTACT
摘要
PRINCIPLE 是一个基于先前发表的算法 PRINCE 的 Java 应用程序，作为 Cytoscape 的一个插件实现。给定一个查询疾病，它会根据疾病相关基因与导致查询疾病表型相似的疾病的基因在蛋白质-蛋白质相互作用网络中的接近程度，对这些基因进行优先级排序。
可用性
PRINCIPLE 用 Java 实现，可在 Cytoscape 2.7 或更高版本上运行。二进制文件、默认输入文件和文档可在 http://www.cs.tau.ac.il/~bnet/software/PrincePlugin/ 免费获得。
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