White Robin J, Budarin Vitaly L, Moir James W B, Clark James H
Green Chemistry Centre of Excellence, Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK; E-Mails:
Int J Mol Sci. 2011;12(9):5782-96. doi: 10.3390/ijms12095782. Epub 2011 Sep 9.
Silver nanoparticles (AgNP) confined within porous starch have been prepared in a simple, green and efficient manner, utilising the nanoporous structure of predominantly mesoporous starch (MS) to act as nanoparticle stabiliser, support and reducing surface. MS/AgNP materials present high surface areas (S(BET) > 150 m(2) g(-1)) and mesopore volumes (V(meso) > 0.45 cm(3) g(-1)). The interaction of the AgNP precursor and forming nanoparticle nuclei with the mesoporous domains of the porous polysaccharide, direct porosity to increasingly narrower and more defined pore size distributions, indicative of a degree of cooperative assembly. Transmission electron microscopy images indicated the presence of spherical AgNP of a size reflective of the porous polysaccharide mesopore diameter (e.g., 5-25 nm), whilst XPS analysis confirmed the metallic Ag(0) state. Materials were prepared at relatively low Ag loadings (<0.18 mmol g(-1)), demonstrating excellent antimicrobial activity in solid and liquid phase testing against Gram negative (E. coli) and positive (S. aureus) model bacteria. The resulting materials are biocompatible and present a useful solid porous carbohydrate-based polymer vehicle to control the AgNP size regime and facilitate transference to a biological environment.
采用简单、绿色且高效的方式制备了限制在多孔淀粉内的银纳米颗粒（AgNP），利用主要为介孔淀粉（MS）的纳米多孔结构作为纳米颗粒的稳定剂、载体和还原表面。MS/AgNP材料具有高比表面积（S(BET) > 150 m(2) g(-1)）和介孔体积（V(meso) > 0.45 cm(3) g(-1)）。AgNP前体与形成的纳米颗粒核与多孔多糖的介孔区域相互作用，使孔隙率逐渐变窄且孔径分布更明确，这表明存在一定程度的协同组装。透射电子显微镜图像表明存在尺寸与多孔多糖介孔直径相当（例如5 - 25 nm）的球形AgNP，而XPS分析证实了金属Ag(0)状态。材料在相对较低的Ag负载量（<0.18 mmol g(-1)）下制备，在针对革兰氏阴性（大肠杆菌）和阳性（金黄色葡萄球菌）模型细菌的固相和液相测试中表现出优异的抗菌活性。所得材料具有生物相容性，是一种有用的基于固体多孔碳水化合物的聚合物载体，可控制AgNP的尺寸范围并促进向生物环境的转移。
