抑制如何塑造皮层活动。
How inhibition shapes cortical activity.
机构信息
Center for Neural Circuits and Behavior, University of California San Diego, La Jolla, CA 92093-0634, USA.
出版信息
Neuron. 2011 Oct 20;72(2):231-43. doi: 10.1016/j.neuron.2011.09.027.
Abstract
Cortical processing reflects the interplay of synaptic excitation and synaptic inhibition. Rapidly accumulating evidence is highlighting the crucial role of inhibition in shaping spontaneous and sensory-evoked cortical activity and thus underscores how a better knowledge of inhibitory circuits is necessary for our understanding of cortical function. We discuss current views of how inhibition regulates the function of cortical neurons and point to a number of important open questions.
摘要
皮层处理反映了突触兴奋和抑制的相互作用。快速积累的证据强调了抑制在塑造自发性和感觉诱发皮层活动中的关键作用，因此突显了更好地了解抑制回路对于理解皮层功能的必要性。我们讨论了当前关于抑制如何调节皮层神经元功能的观点，并指出了一些重要的开放性问题。
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