本地微生物群影响昆虫媒介对人类病原体的易感性。
Native microbiota shape insect vector competence for human pathogens.
机构信息
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205-2179, USA.
出版信息
Cell Host Microbe. 2011 Oct 20;10(4):307-10. doi: 10.1016/j.chom.2011.09.006.
Abstract
The resident microbiota of insect vectors can impede transmission of human pathogens. Recent studies have highlighted the capacity of endogenous bacteria to decrease viral and parasitic infections in mosquito and tsetse fly vectors by activating their immune responses or directly inhibiting pathogen development. These microbes may prove effective agents for manipulating the vector competence of malaria and other important human pathogens.
摘要
昆虫媒介的常驻微生物群可能会阻碍人类病原体的传播。最近的研究强调了内源性细菌通过激活其免疫反应或直接抑制病原体发育，从而降低蚊子和采采蝇媒介中病毒和寄生虫感染的能力。这些微生物可能成为操纵疟疾和其他重要人类病原体媒介能力的有效手段。
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