Department of Epidemiology and Public Health, Yale School of Public Health, New Haven, CT 06520, USA.
Trends Parasitol. 2011 Nov;27(11):514-22. doi: 10.1016/j.pt.2011.05.001. Epub 2011 Jun 21.
Insect symbioses lack the complexity and diversity of those associated with higher eukaryotic hosts. Symbiotic microbiomes are beneficial to their insect hosts in many ways, including dietary supplementation, tolerance to environmental perturbations and maintenance and/or enhancement of host immune system homeostasis. Recent studies have also highlighted the importance of the microbiome in the context of host pathogen transmission processes. Here we provide an overview of the relationship between insect disease vectors, such as tsetse flies and mosquitoes, and their associated microbiome. Several mechanisms are discussed through which symbiotic microbes can influence the ability of their host to transmit pathogens, as well as potential disease control strategies that harness symbiotic microbes to reduce pathogen transmission through an insect vector.
昆虫共生体缺乏与高等真核宿主相关的复杂性和多样性。共生微生物组在许多方面对其昆虫宿主有益，包括膳食补充、耐受环境干扰以及维持和/或增强宿主免疫系统的稳态。最近的研究还强调了微生物组在宿主病原体传播过程中的重要性。在这里，我们概述了疾病传播媒介昆虫（如采采蝇和蚊子）与其相关微生物组之间的关系。讨论了几种机制，通过这些机制共生微生物可以影响其宿主传播病原体的能力，以及利用共生微生物通过昆虫媒介减少病原体传播的潜在疾病控制策略。
