Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Dermatology. 2011;223(2):174-81. doi: 10.1159/000332847. Epub 2011 Oct 21.
Obtaining good adherence to acne therapy is a challenge for all dermatologists. We studied 428 acne patients in Japan to determine the likelihood of good adherence and factors associated with medication-taking. This study utilized a simple validated questionnaire to assess risk of poor adherence; information about patient and treatment characteristics was also collected. There was an overall rate of poor adherence in 76% of subjects. Adherence to topical medication was poor in 52% of those treated with a topical agent only (n = 123). Among those taking combination therapies (n = 275), adherence to the topical portion of therapy was poor in 49% of subjects. The likelihood of poor adherence to oral medication was higher, both when administered alone (n = 30, 93% poor adherence) and when given as part of a combination regimen (n = 275, 86%). Factors with an impact on adherence included satisfaction with treatment (p = 0.023) and the experience of side effects (p = 0.027). Patients who felt they had a good understanding of acne and its treatment were more likely to have good adherence. These data suggest that there is significant room for improvement in acne adherence in Japan, as in other areas of the world, and that improved education may enhance adherence.
对于所有皮肤科医生来说，获得良好的痤疮治疗依从性都是一个挑战。我们在日本研究了 428 例痤疮患者，以确定良好依从性的可能性和与药物治疗相关的因素。本研究利用简单的验证问卷来评估药物治疗依从性的风险；还收集了有关患者和治疗特点的信息。在 76%的患者中存在总体依从性差的情况。在仅接受局部治疗的患者中（n = 123），有 52%的患者局部用药依从性差。在接受联合治疗的患者中（n = 275），有 49%的患者治疗局部部分的依从性差。单独给予口服药物治疗（n = 30，93%的患者依从性差）和作为联合治疗方案的一部分给予口服药物治疗（n = 275，86%的患者依从性差）的患者，药物治疗依从性差的可能性更高。影响依从性的因素包括对治疗的满意度（p = 0.023）和副作用的体验（p = 0.027）。认为自己对痤疮及其治疗有很好了解的患者更有可能有良好的依从性。这些数据表明，日本乃至世界各地的痤疮患者的依从性都有很大的改善空间，而改善教育可能会提高依从性。
