1st Department of Dermatology, Andreas Sygros Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
J Am Acad Dermatol. 2012 Feb;66(2):271-7. doi: 10.1016/j.jaad.2011.07.024. Epub 2011 Oct 27.
Unwanted tattoos are treated with Q-switched lasers. Despite a series of treatments, efficacy is limited.
We compared a single Q-switched laser treatment pass with 4 treatment passes separated by 20 minutes.
Eighteen tattoos on 12 adults were divided in half and randomized. One half received a single treatment pass (the "conventional" method) with a Q-switched alexandrite laser (5.5 J/cm(2), 755 nm, 100-nanosecond pulse duration, 3-mm spot size), and the other half received 4 treatment passes with an interval of 20 minutes between passes (the "R20" method). Tattoo lightening was compared 3 months later, by blinded evaluation of photographs. Biopsy specimens obtained before and immediately after treatment on both halves were also compared in blinded fashion.
Immediate whitening reaction occurred on the first treatment pass, with little or no whitening on subsequent passes. Three months later, treatment with the R20 method was much more effective than conventional single-pass laser treatment (P <.01; all tattoos favored the R20 method). Despite greater epidermal injury with the R20 method, neither method caused adverse events or scarring. Light microscopy showed greater dispersion of tattoo ink with the R20 method.
This prospective study involved a small number of subjects.
The R20 method is much more effective than conventional laser tattoo treatment, removing most tattoos in a single treatment session. New laser device technology is not required to practice this method.
Q 开关激光可用于去除不想要的纹身。尽管经过一系列治疗，疗效仍有限。
我们比较了单次 Q 开关激光治疗与 20 分钟间隔的 4 次治疗的效果。
12 名成年人的 18 处纹身被分为两半并随机分组。一半接受单次治疗（“常规”法），使用 Q 开关亚历山大石激光（5.5 J/cm²，755nm，100 纳秒脉冲持续时间，3mm 光斑大小），另一半接受 4 次治疗，每次治疗间隔 20 分钟（“R20”法）。3 个月后通过对照片进行盲法评估比较纹身褪色情况。还以盲法比较了两半部治疗前后即刻获得的活检标本。
首次治疗即刻出现变白反应，随后的治疗中变白反应较小或没有。3 个月后，R20 法治疗比常规单次激光治疗更有效（P<.01；所有纹身都更倾向于 R20 法）。尽管 R20 法引起更大的表皮损伤，但两种方法均未引起不良事件或瘢痕。光镜显示 R20 法使纹身颜料的分散性更大。
本前瞻性研究纳入的受试者数量较少。
R20 法比常规激光纹身治疗更有效，单次治疗即可去除大多数纹身。不需要新的激光设备技术即可实施该方法。
